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Metabolic & GLP-1
236 · drugs91 · with routes54 · with on-sale intermediates
236 patent-cliff drugs in Metabolic & GLP-1 (classified by indication keywords and explicit molecule lists from our structured data), 91 with recorded synthesis routes and 54 with on-sale intermediates. Every "Available" badge links to real listings for RFQ.
| Drug | Tier | Expiry | Indications | Routes | CAS count | Available |
|---|---|---|---|---|---|---|
| Finerenone | C · Watch | 2030 | Systolic heart failure, Diastolic heart failure, Heart failure | 35 | 96 | Available ×96 |
| Ertugliflozin | C · Watch | - | Type 2 diabetes | 4 | 48 | Available ×48 |
| Empagliflozin | A · Act now | 2028 | Chronic renal impairment, Heart failure, Type 2 diabetes | 3 | 24 | Available ×24 |
| Linagliptin | C · Watch | 2029 | Type 2 diabetes | 4 | 21 | Available ×21 |
| Lifitegrast | C · Watch | - | Dry eye disease, Dry eye syndrome | 1 | 20 | Available ×20 |
| Mirogabalin besilate | C · Watch | 2030 | Diabetic neuropathy, Postherpetic neuralgia, Peripheral nervous system disorder | 2 | 14 | Available ×14 |
| Sotagliflozin | C · Watch | 2032 | Type 2 diabetes, Chronic renal impairment, Heart failure | 1 | 14 | Available ×14 |
| Vericiguat | C · Watch | - | Heart failure | 1 | 12 | Available ×12 |
| Tenapanor hydrochloride | C · Watch | - | Hyperphosphataemia, Chronic renal impairment, Constipation | 1 | 10 | Available ×10 |
| Alogliptin Benzoate | C · Watch | - | Type 2 diabetes | 4 | 24 | Available ×9 |
| Lanifibranor | C · Watch | - | Non-alcoholic steatohepatitis, Type 2 diabetes, 弥漫性硬皮病 | 2 | 9 | Available ×9 |
| Nebivolol Hydrochloride | C · Watch | - | Hypertension | 1 | 8 | Available ×8 |
| Dapagliflozin Propanediol/Metformin Hydrochloride | A · Act now | 2030 | Type 2 diabetes | 4 | 16 | Available ×6 |
| Sitagliptin Phosphate Monohydrate/Ipragliflozin L-Proline | C · Watch | - | Type 2 diabetes | 4 | 16 | Available ×6 |
| Dapagliflozin Propanediol Monohydrate | B · Position early | - | Chronic renal impairment, Heart failure, Kidney disease | 4 | 16 | Available ×6 |
| Ipragliflozin L-Proline | C · Watch | - | Type 2 diabetes, Type 1 diabetes | 4 | 16 | Available ×6 |
| Alogliptin Benzoate/Pioglitazone Hydrochloride | C · Watch | - | Type 2 diabetes | 5 | 28 | Available ×5 |
| Pioglitazone Hydrochloride | B · Position early | - | Type 2 diabetes | 5 | 28 | Available ×5 |
| Dapagliflozin Propanediol Monohydrate/Saxagliptin Hydrochloride | C · Watch | - | Type 2 diabetes | 4 | 48 | Available ×5 |
| Saxagliptin Hydrate | B · Position early | - | Type 2 diabetes | 4 | 48 | Available ×5 |
| Canagliflozin/Metformin Hydrochloride | B · Position early | 2029 | End-stage renal disease, Cardiac and vascular disorders, Abdominal aortic aneurysm | 3 | 19 | Available ×5 |
| Canagliflozin Hemihydrate | C · Watch | - | Type 2 diabetes, Diabetic nephropathy | 3 | 19 | Available ×5 |
| Enalapril Maleate | C · Watch | - | Heart failure, Hypertension, Myocardial infarction | 14 | 69 | Available ×4 |
| Atorvastatin Calcium Hydrate/Metformin Hydrochloride | C · Watch | - | Type 2 diabetes, Hyperlipidaemia | 5 | 55 | Available ×4 |
| Atorvastatin Calcium Hydrate | B · Position early | - | Hyperlipoproteinaemia type III, Hyperlipidaemia, Heterozygous familial hypercholesterolaemia | 5 | 55 | Available ×4 |
| Yogliptin | C · Watch | - | Type 2 diabetes | 1 | 7 | Available ×4 |
| Vildagliptin | B · Position early | - | Type 2 diabetes | 6 | 25 | Available ×3 |
| Mitiglinide | C · Watch | - | Type 2 diabetes | 5 | 29 | Available ×3 |
| Orlistat | C · Watch | - | Obesity | 5 | 80 | Available ×3 |
| Trelagliptin Succinate | C · Watch | - | Type 2 diabetes | 3 | 16 | Available ×3 |
| Astaxanthin | C · Watch | - | 营养失调 | 14 | 30 | Available ×2 |
| Telmisartan | B · Position early | - | Hypertension | 5 | 35 | Available ×2 |
| Irbesartan | B · Position early | - | Oesophageal disease, Hypertension, Diabetic nephropathy | 5 | 29 | Available ×2 |
| Pregabalin | B · Position early | - | Fibromyalgia, Seizure, Postherpetic neuralgia | 5 | 28 | Available ×2 |
| Vorolanib | C · Watch | - | Renal cell carcinoma | 1 | 6 | Available ×2 |
| Pradigastat | C · Watch | - | Constipation, I型高脂蛋白血症, Hypertriglyceridaemia | 1 | 11 | Available ×2 |
| Tirzepatide | B · Position early | 2036 | Obstructive sleep apnoea syndrome, Obesity, Overweight | 9 | 1 | Available ×1 |
| Desvenlafaxine Succinate Hydrate | C · Watch | - | Depressive disorder, Major depressive disorder | 6 | 22 | Available ×1 |
| Donepezil Hydrochloride | B · Position early | - | Lewy body dementia, Alzheimer's disease, Dementia | 5 | 20 | Available ×1 |
| Bosentan Hydrate | B · Position early | - | 溃疡, Pulmonary arterial hypertension, Pulmonary hypertension | 5 | 18 | Available ×1 |
| Entacapone | C · Watch | - | Parkinson's disease | 5 | 16 | Available ×1 |
| Alprazolam | C · Watch | - | Anxiety disorder, Panic disorder | 3 | 12 | Available ×1 |
| Muvalaplin | C · Watch | - | Atherosclerosis, 脂类代谢紊乱, Renal impairment | 3 | 4 | Available ×1 |
| Inavolisib | C · Watch | - | Breast cancer, Metastatic breast cancer | 2 | 19 | Available ×1 |
| Amlodipine Maleate | C · Watch | - | Hypertension, Angina pectoris | 2 | 10 | Available ×1 |
| Nadolol | C · Watch | - | Diabetic macular oedema, Diabetic retinopathy, 感染性角结膜炎 | 2 | 9 | Available ×1 |
| Fultagliptin Benzoate | C · Watch | - | Type 2 diabetes | 1 | 10 | Available ×1 |
| Retagliptin Phosphate | C · Watch | - | Type 2 diabetes | 1 | 13 | Available ×1 |
| Henagliflozin Proline | C · Watch | - | Type 2 diabetes | 1 | 15 | Available ×1 |
| Chiglitazar Sodium | C · Watch | - | Type 2 diabetes | 1 | 5 | Available ×1 |
| Elismetrep | C · Watch | - | Migraine, 糖尿病周围神经病变, Hot flushes | 1 | 9 | Available ×1 |
| Rifaquizinone | C · Watch | - | 假体相关感染, 糖尿病足溃疡, Infectious skin disease | 1 | 12 | Available ×1 |
| Rimiducid | C · Watch | - | 大B细胞淋巴瘤, Hodgkin's disease, Non-Hodgkin lymphoma | 1 | 13 | Available ×1 |
| Nabilone | C · Watch | - | Pruritus, End-stage renal disease, Nausea | 1 | 8 | Available ×1 |
| Ramipril | C · Watch | - | Hypertension, Nephropathy, Myocardial infarction | 15 | 38 | - |
| Setmelanotide Acetate | C · Watch | - | 下丘脑肥胖, 巴德特-别德尔综合征, Obesity | 7 | 29 | - |
| Azilsartan | C · Watch | - | Hypertension | 6 | 20 | - |
| Formoterol Fumarate | C · Watch | - | Chronic obstructive pulmonary disease, Emphysema, Asthma | 6 | 6 | - |
| Olmesartan Medoxomil | B · Position early | - | Hypertension | 5 | 19 | - |
| Atazanavir Sulfate | B · Position early | - | HIV infection | 5 | 35 | - |
| Fondaparinux Sodium | C · Watch | - | Pulmonary embolism, Venous thrombosis, Myocardial infarction | 5 | 43 | - |
| Bremelanotide | C · Watch | - | Psychogenic sexual dysfunction | 4 | 1 | - |
| Topiroxostat | C · Watch | - | Hyperuricaemia, Gout | 4 | 13 | - |
| Levothyroxine Sodium | B · Position early | - | Coma, 粘液性水肿昏迷, Hypothyroidism | 4 | 14 | - |
| Cetilistat | C · Watch | - | Obesity | 3 | 9 | - |
| Fenofibrate | C · Watch | - | Hypercholesterolaemia, Hypertriglyceridaemia | 3 | 5 | - |
| Chlorthalidone | C · Watch | - | Hypertension, Oedema, Diabetes insipidus | 2 | 4 | - |
| Risedronate Sodium Hydrate | C · Watch | - | Paget's disease, Postmenopausal osteoporosis, Osteoporosis | 2 | 3 | - |
| Levoketoconazole | C · Watch | - | Cushing's syndrome | 2 | 11 | - |
| Tirbanibulin | C · Watch | - | Actinic keratosis | 2 | 12 | - |
| Obicetrapib | C · Watch | - | Myocardial infarction, Atherosclerosis, Hypercholesterolaemia | 2 | 8 | - |
| Imarikiren hydrochloride | C · Watch | - | Hypertension, Diabetic nephropathy, Hepatic function decline | 2 | 27 | - |
| Apabetalone | C · Watch | - | 新冠后遗症, End-stage renal disease, Pulmonary arterial hypertension | 2 | 5 | - |
| PEG-Loxenatide | C · Watch | - | Type 2 diabetes | 1 | 2 | - |
| Lobeglitazone Sulfate | C · Watch | - | Type 2 diabetes | 1 | 9 | - |
| Misoprostol | C · Watch | - | Termination of pregnancy, Duodenal ulcer, Gastric ulcer | 1 | 5 | - |
| Naloxone Hydrochloride | C · Watch | - | Opioid dependence, 中毒 | 1 | 8 | - |
| Cofrogliptin | C · Watch | - | Type 2 diabetes | 1 | 8 | - |
| Elafibranor | C · Watch | - | Sclerosing cholangitis, Biliary cirrhosis | 1 | 5 | - |
| Anamorelin Hydrochloride | C · Watch | - | Cachexia | 1 | 6 | - |
| ATX-304 | C · Watch | - | Type 2 diabetes, 线粒体疾病, Peripheral arterial disease | 1 | 2 | - |
| Sarconeos | C · Watch | - | 肌肉减少症, Overweight, Obesity | 1 | 11 | - |
| PB-201 | C · Watch | - | Type 2 diabetes | 1 | 11 | - |
| Isuzinaxib hydrochloride | C · Watch | - | Diabetic nephropathy, 急性肾损伤, COVID-19 | 1 | 3 | - |
| Tianagliflozin | C · Watch | - | Type 2 diabetes | 1 | 6 | - |
| PXS-4728 | C · Watch | - | REM睡眠行为障碍, Diabetic retinopathy, Non-alcoholic steatohepatitis | 1 | 8 | - |
| Pravibismane | C · Watch | - | 糖尿病足溃疡, Bacterial infection | 1 | 2 | - |
| Cebranopadol hemicitrate | C · Watch | - | Pain, 急性疼痛, 神经痛 | 1 | 7 | - |
| Resveratrol | C · Watch | - | Dyslipidaemia, Peripheral arterial disease, Parkinson's disease | 1 | 7 | - |
| Alvelestat | C · Watch | - | COVID-19, α1抗胰蛋白酶缺乏症, Emphysema | 1 | 11 | - |
| 2-Deoxyglucose | C · Watch | - | Seizure, Overweight, Non-alcoholic steatohepatitis | 1 | 3 | - |
| Glucagon intranasal (Eli Lilly/Locemia Solutions) | C · Watch | - | Hypoglycaemia | - | - | - |
| Angiotensin II | C · Watch | - | Hypotension, Shock | - | - | - |
| Sitagliptin/Ertugliflozin | C · Watch | - | Type 2 diabetes | - | - | - |
| Metformin Hydrochloride/Ertugliflozin | C · Watch | - | Type 2 diabetes | - | - | - |
| Iron Isomaltoside | C · Watch | - | Iron deficiency anaemia | - | - | - |
| Linagliptin/Empagliflozin | C · Watch | - | Cardiac and vascular disorders, Type 2 diabetes | - | - | - |
| Gemigliptin L-tartrate Sesquihydrate/Metformin Hydrochloride | C · Watch | - | Type 2 diabetes | - | - | - |
| Metformin acetate | C · Watch | - | Obesity, Diabetes | - | - | - |
| Linagliptin/Metformin Hydrochloride | B · Position early | - | Type 2 diabetes | - | - | - |
| Rosilitazone Tartrate | C · Watch | - | Type 2 diabetes | - | - | - |
| Bupropion hydrobromide | C · Watch | - | Seasonal affective disorder, Major depressive disorder | - | - | - |
| Vildagliptin/Metformin Hydrochloride | C · Watch | - | Type 2 diabetes | - | - | - |
| Semaglutide | A · Act now | 2031 | Overweight, Obesity, Type 2 diabetes | - | - | - |
| Crisugabalin Besilate | C · Watch | - | Postherpetic neuralgia, Diabetic neuropathy | - | - | - |
| Enavogliflozin/Metformin Hydrochloride | C · Watch | - | Type 2 diabetes | - | - | - |
| Dapagliflozin Propanediol Hydrate/Sitagliptin Phosphate Hydrate | C · Watch | - | Type 2 diabetes | - | - | - |
| Glimepiride/Dapagliflozin Propanediol Monohydrate | C · Watch | - | Type 2 diabetes | - | - | - |
| Triamcinolone Acetonide Suprachoroidal Injectable Suspension(Arctic Vision) | C · Watch | - | 黄斑水肿, 葡萄膜炎 | - | - | - |
| Sitagliptin Tartrate | C · Watch | - | Non-alcoholic steatohepatitis, Diabetic nephropathy, Type 1 diabetes | - | - | - |
| Diperoxochloric acid | C · Watch | - | 糖尿病足溃疡 | - | - | - |
| Lidocaine Cataplasms(Beijing Tide Pharma) | C · Watch | - | 糖尿病周围神经性疼痛, Postherpetic neuralgia | - | - | - |
| Repaglinide/Metformin Hydrochloride | C · Watch | - | Type 2 diabetes | - | - | - |
| Secretin | C · Watch | - | 胰腺疾病, Contrast imaging, Diagnostic agent | - | - | - |
| Glucosamine Hydrochloride | C · Watch | - | Osteoarthritis | - | - | - |
| Glyburide/Metformin Hydrochloride | C · Watch | - | Type 2 diabetes | - | - | - |
| Colesevelam Hydrochloride | C · Watch | - | Hypercholesterolaemia, Hyperlipoproteinaemia type II, Type 2 diabetes | - | - | - |
| Tetrachlorodecaoxide | C · Watch | - | Allergic rhinitis, Inflammatory disease | - | - | - |
| AD-233 | C · Watch | - | Type 2 diabetes | - | - | - |
| AZD-6234 | C · Watch | - | Overweight, Obesity, Type 2 diabetes | - | - | - |
| GUB-014295 | C · Watch | - | Overweight, Obesity | - | - | - |
| BI-3034701 | C · Watch | - | Overweight, Obesity | - | - | - |
| UBT-251 | C · Watch | - | Obesity, Obstructive sleep apnoea syndrome, Type 2 diabetes | - | - | - |
| ERX-1000 | C · Watch | - | Overweight, Obesity | - | - | - |
| YJ001 | C · Watch | - | 糖尿病周围神经性疼痛, 糖尿病周围神经病变, Diabetic neuropathy | - | - | - |
| Enicepatide | C · Watch | - | Overweight, Obesity, Type 2 diabetes | - | - | - |
| HRS-1780 | C · Watch | - | Hypertension, Chronic renal impairment, 醛固酮增多症 | - | - | - |
| ALN-2232 | C · Watch | - | Obesity | - | - | - |
| ATR-258 | C · Watch | - | Overweight, Obesity, Type 2 diabetes | - | - | - |
| LY-4065967 | C · Watch | - | Low back pain, Chronic pain, Knee arthritis | - | - | - |
| MOTS-c | C · Watch | - | Overweight, Obesity, 糖尿病前期 | - | - | - |
| MDR-001 | C · Watch | - | Overweight, Obesity, Hypertension | - | - | - |
| Kamuvudine-9 | C · Watch | - | Diabetic macular oedema, 甲状腺相关性眼病 | - | - | - |
| BAFA | C · Watch | - | 钙代谢障碍 | - | - | - |
| ACCG-2671 | C · Watch | - | Obesity | - | - | - |
| ECC-4703 | C · Watch | - | Obesity, 体重, Non-alcoholic steatohepatitis | - | - | - |
| Linafexor | C · Watch | - | Sclerosing cholangitis, Biliary cirrhosis, Non-alcoholic steatohepatitis | - | - | - |
| LY-3537021 | C · Watch | - | Chemotherapy-induced nausea and vomiting, Nausea, 呕吐 | - | - | - |
| RN-3161 | C · Watch | - | Overweight, Obesity | - | - | - |
| HRS-5632 | C · Watch | - | 脂类代谢紊乱, Dyslipidaemia | - | - | - |
| Macupatide | C · Watch | - | Overweight, Type 2 diabetes, Obesity | - | - | - |
| BM-2216 | C · Watch | - | Diabetic neuropathy, Diabetes, 糖尿病周围神经性疼痛 | - | - | - |
| Brenipatide | C · Watch | - | Depressive disorder, Alcohol abuse, Major depressive disorder | - | - | - |
| S1B-509 | C · Watch | - | Obesity | - | - | - |
| LY-3938577 | C · Watch | - | Type 2 diabetes, Type 1 diabetes | - | - | - |
| bis-octanoyl (R)-1,3-butanediol (C8 ketone di-ester) | C · Watch | - | Non-alcoholic steatohepatitis, Obesity | - | - | - |
| Deziglipel | C · Watch | - | Type 2 diabetes, Obesity | - | - | - |
| VK-2735 | C · Watch | - | Obesity, 体重减轻, Non-alcoholic steatohepatitis | - | - | - |
| RAY-1225 | C · Watch | - | Type 2 diabetes, Overweight, Obesity | - | - | - |
| HS-10501 | C · Watch | - | Type 2 diabetes, Overweight, Obesity | - | - | - |
| Meglumine Sodium Succinate | C · Watch | - | 糖尿病酮症酸中毒, 酸中毒 | - | - | - |
| PF-08653945 | C · Watch | - | Overweight, Obesity, 体重 | - | - | - |
| ALN-4324 | C · Watch | - | Overweight, Type 2 diabetes, Obesity | - | - | - |
| GLK-401 | C · Watch | - | 年龄相关性黄斑变性, 视网膜静脉阻塞, Diabetic macular oedema | - | - | - |
| Semaglutide(Zhejiang Apeloa Kangyu Pharma) | C · Watch | - | 体重, Type 2 diabetes, Cardiac and vascular disorders | - | - | - |
| Oruvestat | C · Watch | - | Diabetic retinopathy, Diabetic macular oedema | - | - | - |
| EOM147 | C · Watch | - | 黄斑水肿, 湿性年龄相关性黄斑变性, Diabetic retinopathy | - | - | - |
| Naperiglipron | C · Watch | - | Overweight, Obesity, Type 2 diabetes | - | - | - |
| QB0208-1 | C · Watch | - | Benign prostatic hyperplasia, Hypercholesterolaemia, 糖尿病足溃疡 | - | - | - |
| Fluocinolone acetonide (FA) extended release(Eclipse Life Sciences) | C · Watch | - | Diabetic macular oedema | - | - | - |
| Visepegenatide | C · Watch | - | Type 2 diabetes | - | - | - |
| Henagliflozin/metformin/retagliptin (Shandong Shengdi) | C · Watch | - | Type 2 diabetes, Diabetes | - | - | - |
| BR1019 | C · Watch | - | Hypertension, Diabetes, Type 2 diabetes | - | - | - |
| Vicadrostat | C · Watch | - | Chronic renal impairment, Type 2 diabetes, Hypertension | - | - | - |
| Cadisegliatin | C · Watch | - | Type 1 diabetes, Type 2 diabetes | - | - | - |
| Zabopegdutide | C · Watch | - | Overweight, Non-alcoholic steatohepatitis, Obesity | - | - | - |
| Lipoic acid/Mecobalamin/Vitamin B1/Vitamin B6 | C · Watch | - | Diabetic neuropathy | - | - | - |
| Dapagliflozin/Rosuvastatin (Cmg Pharmaceutical) | C · Watch | - | Type 2 diabetes, Dyslipidaemia | - | - | - |
| Sustained released intravitreal implants(University of Kentucky) | C · Watch | - | 地图状萎缩, 年龄相关性黄斑变性, Diabetic macular oedema | - | - | - |
| NN-9505 | C · Watch | - | Obesity | - | - | - |
| VI-0809 | C · Watch | - | Diabetes | - | - | - |
| VI-0810 | C · Watch | - | Diabetes | - | - | - |
| ATB-101 | C · Watch | - | Type 2 diabetes, Hypertension | - | - | - |
| AT-003(Arctic Therapeutics) | C · Watch | - | Multiple sclerosis, Rheumatoid arthritis, Parkinson's disease | - | - | - |
| dapagliflozin formate | C · Watch | - | Diabetes, Breast cancer, Type 2 diabetes | - | - | - |
| AZD9550 | C · Watch | - | Overweight, Obesity, Hepatic function decline | - | - | - |
| K-833 | C · Watch | - | Obesity, Type 2 diabetes, 代谢病 | - | - | - |
| K-757 | C · Watch | - | Obesity, Type 2 diabetes, 代谢病 | - | - | - |
| Vanoglipel | C · Watch | - | Non-alcoholic steatohepatitis, Type 2 diabetes | - | - | - |
| PB-718 | C · Watch | - | Obesity, Overweight, 先天性高胰岛素血症 | - | - | - |
| ENERGI-F703 | C · Watch | - | Trauma and injury, Diabetes, 糖尿病足溃疡 | - | - | - |
| AZD-2693 | C · Watch | - | Non-alcoholic steatohepatitis, Liver cirrhosis, 代谢病 | - | - | - |
| CU-06 | C · Watch | - | Diabetic macular oedema, Ulcerative colitis, Lung disease | - | - | - |
| Empagliflozin/Sitagliptin Hydrochloride | C · Watch | - | Type 2 diabetes | - | - | - |
| Tigulixostat | C · Watch | - | Hyperuricaemia, Gout, 痛风性关节炎 | - | - | - |
| ASC-41 | C · Watch | - | Non-alcoholic steatohepatitis, Overweight, Obesity | - | - | - |
| D-4517 | C · Watch | - | 年龄相关性黄斑变性, Diabetic macular oedema | - | - | - |
| Singletine | C · Watch | - | Type 2 diabetes, 脂肪肝 | - | - | - |
| OPL-0401 | C · Watch | - | Diabetic retinopathy | - | - | - |
| MG-O-1002 | C · Watch | - | 年龄相关性黄斑变性, 视网膜静脉阻塞, Diabetic macular oedema | - | - | - |
| TERN-501 | C · Watch | - | Non-alcoholic steatohepatitis, Obesity | - | - | - |
| Irbesartan/Propagermanium | C · Watch | - | 局灶性节段性肾小球硬化症, Diabetic nephropathy | - | - | - |
| RGT-075 | C · Watch | - | Overweight, Obesity, Type 2 diabetes | - | - | - |
| Fulimetibant | C · Watch | - | 神经痛, Diabetes, 糖尿病周围神经病变 | - | - | - |
| CPL207-280CA | C · Watch | - | Diabetes, Diabetic neuropathy, Type 2 diabetes | - | - | - |
| RBD-4988 | C · Watch | - | Type 2 diabetes | - | - | - |
| NBT-NM108 | C · Watch | - | Prader-Willi综合征, Obesity, COVID-19 | - | - | - |
| CS-02 | C · Watch | - | Type 2 diabetes | - | - | - |
| Selonabant | C · Watch | - | 中毒, Obesity | - | - | - |
| EV-077 | C · Watch | - | Diabetic nephropathy, Type 2 diabetes | - | - | - |
| Angiontensin(1-7) | C · Watch | - | 冠状病毒感染, COVID-19, Traumatic brain injury | - | - | - |
| NNC-0165-1875 | C · Watch | - | Obesity, Overweight | - | - | - |
| YG-1699 | C · Watch | - | Type 1 diabetes, Diabetes, Type 2 diabetes | - | - | - |
| Dexlipoic acid lysine | C · Watch | - | 糖尿病周围神经病变, Diabetic neuropathy | - | - | - |
| Dapagliflozin formate/Linagliptin | C · Watch | - | Type 2 diabetes | - | - | - |
| Avenciguat | C · Watch | - | Systemic sclerosis, Diabetic nephropathy, Chronic renal impairment | - | - | - |
| Runcaciguat | C · Watch | - | Diabetic retinopathy, Chronic renal impairment, 蛋白尿 | - | - | - |
| Dapagliflozin/Pioglitazone | C · Watch | - | Diabetes, Type 2 diabetes | - | - | - |
| Exenatide oral (Oramed) | C · Watch | - | Type 2 diabetes | - | - | - |
| kisspeptin 112-121 | C · Watch | - | 闭经, 低促性腺激素性性腺功能减退, Hypogonadism | - | - | - |
| Dexfenfluramine Hydrochloride | C · Watch | - | Solid tumour, Obesity | - | - | - |
| Pilavapadin | C · Watch | - | Diabetic neuropathy, Postherpetic neuralgia, Diabetes | - | - | - |
| THR-149 | C · Watch | - | Diabetes, Diabetic macular oedema, Diabetic retinopathy | - | - | - |
| Efocipegtrutide | C · Watch | - | Non-alcoholic steatohepatitis, Obesity | - | - | - |
| Acarbose/Orlistat | C · Watch | - | Overweight, Obesity | - | - | - |
| Sucunamostat | C · Watch | - | Diabetic nephropathy, Obesity, 枫糖尿病 | - | - | - |
| Deudomperidone | C · Watch | - | 糖尿病胃轻瘫, Gastroparesis | - | - | - |
| Gamma-Tocotrienol | C · Watch | - | Obesity, Menopausal symptoms, Hypercholesterolaemia | - | - | - |
| Zifogaptide | C · Watch | - | 放射性皮炎, 瘢痕, Radiation injury | - | - | - |
| GLWL-01 | C · Watch | - | Alcohol abuse, Type 2 diabetes, Prader-Willi综合征 | - | - | - |
| Cotsiranib | C · Watch | - | Stroke, 基底鳞状细胞癌, 瘢痕疙瘩 | - | - | - |
| Prexigebersen | C · Watch | - | Acute myeloid leukaemia, Peritoneal cancer, Epithelial ovarian cancer | - | - | - |
| Isoquercetin | C · Watch | - | Venous thromboembolism, Pancreatic cancer, Ovarian cancer | - | - | - |
| Dexamethasone intravitreal implant (Aerie Pharmaceuticals) | C · Watch | - | Postoperative pain, 足底筋膜炎, Chemotherapy-induced nausea and vomiting | - | - | - |
| 5-aminolevulinic acid hydrochloride/Sodium ferrous citrate | C · Watch | - | 肾毒性, Anaemia, COVID-19 | - | - | - |
| SYHA1402 | C · Watch | - | 糖尿病周围神经病变, Peripheral nervous system disorder, 糖尿病心肌病 | - | - | - |
| Verenafusp alfa | C · Watch | - | Ⅱ型黏多糖贮积症, 代谢病 | - | - | - |
| NNC0480-0389 | C · Watch | - | Type 2 diabetes, Overweight, Obesity | - | - | - |
| Oral Denatonium Acetate(Aardvark) | C · Watch | - | 体重增长, Obesity, Prader-Willi综合征 | - | - | - |
| Chlorine dioxide (Tarsus Pharmaceuticals) | C · Watch | - | 视网膜病变, Glaucoma, 视网膜静脉阻塞 | - | - | - |
| Dexamethasone ophthalmic (Oculis Pharma) | C · Watch | - | Diabetic macular oedema, 黄斑水肿, Keratitis | - | - | - |
| Adiponectin analogue (Allysta Pharmaceuticals) | C · Watch | - | Dry eye disease, Overweight, Obesity | - | - | - |
| MIB-626 | C · Watch | - | Heart disease, Type 2 diabetes, Diabetic nephropathy | - | - | - |
| Medical Cannabis(Syqe Medical) | C · Watch | - | Diabetic neuropathy, Hepatocellular carcinoma | - | - | - |
| JW-0201 | C · Watch | - | Type 2 diabetes | - | - | - |
| AZD-1656 | C · Watch | - | Type 2 diabetes, Kidney transplant rejection, End-stage renal disease | - | - | - |
Frequently asked questions
Which patent-cliff drugs in Metabolic & GLP-1 are worth tracking?
236 drugs related to Metabolic & GLP-1 are tracked on this site, 91 of them with recorded synthesis routes. See the table above and open each drug profile for routes and intermediates.
Where can I source Metabolic & GLP-1 intermediates?
Key intermediates of 54 drugs in this table are available through the Unibest supply network; for the rest, submit an RFQ per CAS on the intermediate profile pages.
Where can I check patent expiry for these drugs?
Each drug profile shows the public expiry year; yearly overviews are available at /patent-cliff/expires/<year>.
Source: cross-verified structured fields · Classification: indication keywords + explicit molecule lists · 2026-10-22