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Brensocatib

Tier C — Watch / trade

Brensocatib

AstraZeneca
Originator
2025
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type

Targets：CTSC

Brand：Brinsupri

Indications (approved)：Bronchiectasis, Lung disease

Regional status

US
Approved
2025-08-12
EU
Approved
2025-11-18
China
-
Japan
Approved
2026-08-24

Synthetic routes & intermediates2 routes

Originator routes × 0Optimised (non-patent) × 2Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 14 · Total yield 418 g
AZD-79861802148-05-5AZD-7986-00195-85-2AZD-7986-00295-25-0AZD-7986-0035790-90-9AZD-7986-0041220696-32-1AZD-7986-005868694-44-4AZD-7986-0061802153-08-7AZD-7986-0071802153-15-6AZD-7986-0081273567-44-4AZD-7986-0091802150-57-7AZD-7986-010118712-39-3AZD-7986-0111802150-14-6AZD-7986-012922-67-8AZD-7986-0131802150-18-0AZD-7986-0141802150-22-6AZD-7986-0151802150-24-8AZD-7986-0161802150-29-3AZD-7986-0171802150-34-0API · Brensocatib
CodeCAS No.Intermediate
AZD-79861802148-05-5Available-
AZD-7986-00195-85-2Available2-amino-4-chlorophenol
AZD-7986-00295-25-0Available5-chlorobenzo[d]oxazol-2(3H)-one
AZD-7986-0035790-90-9Available5-chloro-3-methylbenzo[d]oxazol-2(3H)-one
AZD-7986-0041220696-32-1Available3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazol-2(3H)-one
AZD-7986-005868694-44-4Availabletert-butyl (S)-(1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbamate
AZD-7986-0061802153-08-7Availabletert-butyl (S)-(1-amino-3-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)-1-oxopropan-2-yl)carbamate
AZD-7986-0071802153-15-6Available(S)-2-amino-3-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)propanamide
AZD-7986-0081273567-44-4Available(S)-4-(tert-butoxycarbonyl)-1,4-oxazepane-2-carboxylic acid
AZD-7986-0091802150-57-7Availabletert-butyl (S)-2-(((S)-1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)carbamoyl)-1,4-oxazepane-4-carboxylate
AZD-7986-010118712-39-3Available(S)-methyl oxirane-2-carboxylate
AZD-7986-0111802150-14-6Availablemethyl (S)-3-(dibenzylamino)-2-hydroxypropanoate
AZD-7986-012922-67-8Availablemethyl propiolate
AZD-7986-0131802150-18-0Availablemethyl (S,E)-3-((3-(dibenzylamino)-1-methoxy-1-oxopropan-2-yl)oxy)acrylate
AZD-7986-0141802150-22-6Availablemethyl (S)-3-amino-2-(3-methoxy-3-oxopropoxy)propanoate
AZD-7986-0151802150-24-8Availablemethyl (S)-5-oxo-1,4-oxazepane-2-carboxylate
AZD-7986-0161802150-29-3Available4-(tert-butyl) 2-methyl (S)-5-oxo-1,4-oxazepane-2,4-dicarboxylate
AZD-7986-0171802150-34-0Available4-(tert-butyl) 2-methyl (S)-1,4-oxazepane-2,4-dicarboxylate
OptimisedRoute 2Steps 11 · Total yield 230 mg
AZD-79861802148-05-5AZD-7986-00295-25-0AZD-7986-0035790-90-9AZD-7986-005868694-44-4AZD-7986-0081273567-44-4AZD-7986-0091802150-57-7AZD-7986-01836914-92-8AZD-7986-0191159489-37-8AZD-7986-0201802149-87-6AZD-7986-0211802149-98-9AZD-7986-0221802149-96-7AZD-7986-0234720-29-0AZD-7986-02416495-13-9AZD-7986-0251802150-04-4AZD-7986-0261802150-08-8AZD-7986-027911223-02-4AZD-7986-028201733-56-4API · Brensocatib
CodeCAS No.Intermediate
AZD-79861802148-05-5Available-
AZD-7986-00295-25-0Available5-chlorobenzo[d]oxazol-2(3H)-one
AZD-7986-0035790-90-9Available5-chloro-3-methylbenzo[d]oxazol-2(3H)-one
AZD-7986-005868694-44-4Availabletert-butyl (S)-(1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbamate
AZD-7986-0081273567-44-4Available(S)-4-(tert-butoxycarbonyl)-1,4-oxazepane-2-carboxylic acid
AZD-7986-0091802150-57-7Availabletert-butyl (S)-2-(((S)-1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)carbamoyl)-1,4-oxazepane-4-carboxylate
AZD-7986-01836914-92-8Availablemethyl (chlorosulfonyl)carbamate
AZD-7986-0191159489-37-8Availabletert-butyl (S)-(1-cyano-2-(4-iodophenyl)ethyl)carbamate
AZD-7986-0201802149-87-6Available5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-3-methylbenzo[d]oxazol-2(3H)-one
AZD-7986-0211802149-98-9Availabletert-butyl (S)-(1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)carbamate
AZD-7986-0221802149-96-7Available(S)-2-amino-3-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)propanenitrile
AZD-7986-0234720-29-0Available3-(benzylamino)propan-1-ol
AZD-7986-02416495-13-9Available(S)-2-((benzyloxy)methyl)oxirane
AZD-7986-0251802150-04-4Available(S)-3-(benzyl(3-(benzyloxy)-2-hydroxypropyl)amino)propan-1-ol
AZD-7986-0261802150-08-8Available(S)-4-benzyl-2-((benzyloxy)methyl)-1,4-oxazepane
AZD-7986-027911223-02-4Availabletert-butyl (S)-2-(hydroxymethyl)-1,4-oxazepane-4-carboxylate
AZD-7986-028201733-56-4Available5,5,5',5'-tetramethyl-2,2'-bi(1,3,2-dioxaborinane)

Frequently asked questions

What are the approved indications of Brensocatib?

Approved indications include: Bronchiectasis, Lung disease.

When does the Brensocatib patent expire?

No public expiry year is available for Brensocatib yet; this page updates once verified.

How many synthesis routes are recorded for Brensocatib?

2 synthesis routes are recorded; the shortest is 11 steps with 230 mg total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Brensocatib intermediates?

29 intermediate CAS of Brensocatib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Brensocatib intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-10-22