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Paltusotine
Tier C — Watch / tradePaltusotine
Crinetics Pharmaceuticals Inc
Originator
2025
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：SSTR2
Brand：PALSONIFY
Indications (approved)：Acromegaly
Regional status
US
Approved
2025-09-25
EU
Approved
2026-04-23
China
Discontinued
2021-12-17
Japan
-
Synthetic routes & intermediates3 routes
Originator routes × 0Optimised (non-patent) × 3Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 3 · Total yield /
(I)1055986-1-a145369-94-4(II)1055986-1-a857762-32-4(III)1055986-1-a927801-50-1(IV)1055986-1-a,(IV)1055986-1-c73874-95-0(V)1055986-1-a,(V)1055986-1-c2172875-14-6(VI)1055986-1-a65340-70-7(VII)1055986-1-a—(VIII)1055986-1-a,(VIII)1055986-1-b—(IX)1055986-1-a2172876-20-7(X)1055986-1-a—(XI)1055986-1-a,(XI)1055986-1-c156545-07-2(XII)1055986-1-a—(XIII)1055986-1-a—(XIV)1055986-1-a,(XIV)1055986-1-c2172870-89-0(XV)1055986-1-a,(XV)1055986-1-b13073-28-4(XVI)1055986-1-a2065250-66-8API · Paltusotine
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)1055986-1-a | 145369-94-4 | 6-Bromoquinolin-4-ol |
| (II)1055986-1-a | 857762-32-4 | 6-Bromo-3-chloroquinolin-4-ol |
| (III)1055986-1-a | 927801-50-1 | 4,6-Dibromo-3-chloroquinoline |
| (IV)1055986-1-a,(IV)1055986-1-c | 73874-95-0 | 1,1-Dimethylethyl piperidin-4-ylcarbamate |
| (V)1055986-1-a,(V)1055986-1-c | 2172875-14-6 | N-Boc-1-(6-bromo-3-chloroquinolin-4-yl)piperidin-4-amine |
| (VI)1055986-1-a | 65340-70-7 | 6-Bromo-4-chloroquinoline |
| (VII)1055986-1-a | - | N-Boc-1-(6-bromoquinolin-4-yl)piperidin-4-amine |
| (VIII)1055986-1-a,(VIII)1055986-1-b | - | 2-Hydroxy-3-cyano-potassium phenyltrifluoro borate |
| (IX)1055986-1-a | 2172876-20-7 | (3-Cyano-2-hydroxyphenyl)boronic acid |
| (X)1055986-1-a | - | N-Boc-3-[4-(4-aminopiperidin-1-yl)-3-chloroquinolin-6-yl]-2-hydroxybenzonitrile |
| (XI)1055986-1-a,(XI)1055986-1-c | 156545-07-2 | (3,5-Difluorophenyl)Boranediol |
| (XII)1055986-1-a | - | N-Boc-1-(6-(3-cyano-2-hydroxyphenyl)-3-(3,5-difluorophenyl)quinolin-4-yl)piperidin-4-amine |
| (XIII)1055986-1-a | - | 3-[4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile dihydrogen chloride |
| (XIV)1055986-1-a,(XIV)1055986-1-c | 2172870-89-0 | 3-[4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile |
| (XV)1055986-1-a,(XV)1055986-1-b | 13073-28-4 | 2-Bromo-6-cyanophenol |
| (XVI)1055986-1-a | 2065250-66-8 | 3-Bromo-2-(methoxymethoxy)benzonitrile |
OptimisedRoute 2Steps 4 · Total yield /
(VIII)1055986-1-a,(VIII)1055986-1-b—(XIX)1055986-1-b2361216-95-5(XV)1055986-1-a,(XV)1055986-1-b13073-28-4(XVII)1055986-1-b840481-82-5(XVIII)1055986-1-b—API · Paltusotine
| Code | CAS No. | Intermediate |
|---|---|---|
| (VIII)1055986-1-a,(VIII)1055986-1-b | - | 2-Hydroxy-3-cyano-potassium phenyltrifluoro borate |
| (XIX)1055986-1-b | 2361216-95-5 | 2-Hydroxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile |
| (XV)1055986-1-a,(XV)1055986-1-b | 13073-28-4 | 2-Bromo-6-cyanophenol |
| (XVII)1055986-1-b | 840481-82-5 | 3-Bromo-2-fluorobenzonitrile |
| (XVIII)1055986-1-b | - | 2-Bromo-6-cyanophenyl acetate |
OptimisedRoute 3Steps 5 · Total yield /
(IV)1055986-1-a,(IV)1055986-1-c73874-95-0(V)1055986-1-a,(V)1055986-1-c2172875-14-6(XI)1055986-1-a,(XI)1055986-1-c156545-07-2(XIV)1055986-1-a,(XIV)1055986-1-c2172870-89-0(XX)1055986-1-c927801-17-0(XXI)1055986-1-c2172875-16-8(XXII)1055986-1-c—(XXIII)1055986-1-c—(XXIV)1055986-1-c488713-78-6(XXV)1055986-1-c—API · Paltusotine
| Code | CAS No. | Intermediate |
|---|---|---|
| (IV)1055986-1-a,(IV)1055986-1-c | 73874-95-0 | 1,1-Dimethylethyl piperidin-4-ylcarbamate |
| (V)1055986-1-a,(V)1055986-1-c | 2172875-14-6 | N-Boc-1-(6-bromo-3-chloroquinolin-4-yl)piperidin-4-amine |
| (XI)1055986-1-a,(XI)1055986-1-c | 156545-07-2 | (3,5-Difluorophenyl)Boranediol |
| (XIV)1055986-1-a,(XIV)1055986-1-c | 2172870-89-0 | 3-[4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile |
| (XX)1055986-1-c | 927801-17-0 | 6-Bromo-3,4-dichloroquinoline |
| (XXI)1055986-1-c | 2172875-16-8 | 2-[(2-Methoxyethoxy)methoxy]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile |
| (XXII)1055986-1-c | - | N-Boc-1-(3-chloro-6-[3-cyano-2-(2-methoxy-ethoxymethoxy)-phenyl]-quinolin-4-yl)-piperidin-4-amine |
| (XXIII)1055986-1-c | - | tert-Butyl [1-[3-chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-4-yl]piperidin-4-yl]carbamate |
| (XXIV)1055986-1-c | 488713-78-6 | 3-Bromo-2-[(2-methoxyethoxy)methoxy]benzonitrile |
| (XXV)1055986-1-c | - | tert-Butyl [1-[6-[3-cyano-2-[(2-methoxyethoxy)methoxy]phenyl]-3-(3,5-difluorophenyl)quinolin-4-yl]piperidin-4-yl]carbamate |
Frequently asked questions
What are the approved indications of Paltusotine?
Approved indications include: Acromegaly.
When does the Paltusotine patent expire?
No public expiry year is available for Paltusotine yet; this page updates once verified.
How many synthesis routes are recorded for Paltusotine?
3 synthesis routes are recorded; the shortest is 3 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Paltusotine intermediates?
All intermediates in Paltusotine routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Paltusotine intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-22