CAS 100-46-9

phenylmethanamine1-Phenylmethylamine

Codes: LACO-006, (XIII)638294-2-a, (IX)638294-13-a, (IV)101438-34-a, (II)109067-9-a, VARE-017, L-Demethyl phencynonate hydrochloride-001

Application context (from source-drug indications)

Tonic-clonic seizureLacosamideEpilepsyLacosamidePartial-onset seizureLacosamideSeizureLacosamideSystolic heart failureFinerenoneDiastolic heart failureFinerenoneHeart failureFinerenoneChronic renal impairmentFinerenoneDiabetic nephropathyFinerenoneType 2 diabetesFinerenoneBreast cancerPaclitaxel/Encequidar mesylateAdenocarcinomaPaclitaxel/Encequidar mesylateAngiosarcomaPaclitaxel/Encequidar mesylateSolid tumourPaclitaxel/Encequidar mesylateHypertensionOlmesartan Medoxomil/Amlodipine orotateEssential hypertensionValsartan/Amlodipine OrotateNicotine dependenceVarenicline TartrateNicotine withdrawalVarenicline TartrateSmoking cessationVarenicline TartrateSmoking reductionVarenicline TartrateCannabis dependenceVarenicline TartrateNebulisationVarenicline TartrateVariant anginaAmlodipine OrotateHypertensionAmlodipine OrotateIschaemic heart diseaseAmlodipine OrotateStable anginaAmlodipine OrotatePancreatic cancerPaclitaxelNon-small cell lung cancerPaclitaxelHodgkin's diseasePaclitaxelSeminomaPaclitaxelOvarian cancerPaclitaxelBreast cancerPaclitaxelHypertensionAmlodipine Camsylate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Lacosamide	Tier B — Position early	2028
Finerenone	Tier C — Watch / trade	2030
Paclitaxel/Encequidar mesylate	Tier C — Watch / trade	-
Olmesartan Medoxomil/Amlodipine orotate	Tier C — Watch / trade	-
Valsartan/Amlodipine Orotate	Tier C — Watch / trade	-
Varenicline Tartrate	Tier B — Position early	-
Amlodipine Orotate	Tier C — Watch / trade	-
Paclitaxel	Tier B — Position early	-
Amlodipine Camsylate	Tier C — Watch / trade	-
L-Demethyl Phencynonate Hydrochloride	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

LacosamideOptimised routesteps: 5total yield: 50 g

D-serine→(chloromethanetriyl)tribenzene→trityl-D-serine→phenylmethanamine→(R)-N-benzyl-3-hydroxy-2-(tritylamino)propanamide→(R)-N-benzyl-3-methoxy-2-(tritylamino)propanamide→(R)-2-amino-N-benzyl-3-methoxypropanamide

LacosamideOptimised routesteps: 5total yield: /

phenylmethanamine→(R)-2-amino-N-benzyl-3-methoxypropanamide→ethyl 2,3-dibromopropanoate→sodium methanolate→2-bromo-3-methoxypropanoic acid→N-benzyl-2-bromo-3-methoxypropanamide→2-amino-N-benzyl-3-methoxypropanamide→(2S,3S)-2,3-bis(benzoyloxy)succinic acid

LacosamideOptimised routesteps: 6total yield: 95 mg

phenylmethanamine→N-acetyl-O-methyl-D-serine→methyl D-serinate→diethoxytriphenyl-l5-phosphane→ethyl (R)-aziridine-2-carboxylate→methyl (R)-aziridine-2-carboxylate→ethyl (R)-1-acetylaziridine-2-carboxylate→methyl (R)-1-acetylaziridine-2-carboxylate→ethyl N-acetyl-O-methyl-D-serinate→methyl N-acetyl-O-methyl-D-serinate→4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride→triphenylphosphane→sodium ethanolate

LacosamideOptimised routesteps: 4total yield: 18.7 g

phenylmethanamine→(R)-2-amino-N-benzyl-3-methoxypropanamide→(tert-butoxycarbonyl)-D-serine→N-(tert-butoxycarbonyl)-O-methyl-D-serine→tert-butyl (R)-(1-(benzylamino)-3-methoxy-1-oxopropan-2-yl)carbamate

FinerenoneOptimised routesteps: 7total yield: /

4-Bromo-2-hydroxybenzoic acid→2-Methoxy-4-bromobenzoic acid methyl ester→4-Bromo-2-methoxybenzaldehyde→2-Methoxy-4-cyanobenzaldehyde→3-Oxobutanamide→(2E)-2-[(4-Cyano-2-methoxyphenyl)methylidene]-3-oxobutanamide→(2Z)-2-[(4-Cyano-2-methoxyphenyl)methylidene]-3-oxobutanamide→4-Amino-5-methylpyridin-2(1H)-one→4-(4-Cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxamide→1,1,1-Triethoxyethane→(±)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide→2,4-Dihydroxy-5-methylpyridine→1-Phenylmethylamine→4-(Benzylamino)-5-methylpyridin-2(1H)-one

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Nantong cGMP Site	4-Bromo-2-methoxybenzaldehyde Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	4-formyl-3-methoxybenzonitrile Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	4-AMino-5-Methylpyridin-2-ol Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	2-chloro-5-methylpyridin-4-amine Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	2-Cyanoethyl 3-oxobutanoate Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	1,4-DIHYDRO-1,4-METHANONAPHTHALENE Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	2,3,4,5-Tetrahydro-7,8-dinitro-3-(trifluoroacetyl)-1,5-methano-1H-3-benzazepine Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	2,3,4,5-Tetrahydro-3-(trifluoroacetyl)-1,5-methano-1H-3-benzazepine-7,8-diamine Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.