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CAS 100-58-3

Bromo(phenyl)magnesiumphenylmagnesium bromide

Codes: (I)101438-38-a, (IX)70353-1-a, (II)663167-2-a, Ioflupane (123I)-018, LPHE-004

Application context (from source-drug indications)

Breast cancerPaclitaxel/Encequidar mesylateAdenocarcinomaPaclitaxel/Encequidar mesylateAngiosarcomaPaclitaxel/Encequidar mesylateSolid tumourPaclitaxel/Encequidar mesylateBacterial and fungal infectionBetamethasone/Clotrimazole/Gentamicin SulfatePancreatic cancerPaclitaxelNon-small cell lung cancerPaclitaxelHodgkin's diseasePaclitaxelSeminomaPaclitaxelOvarian cancerPaclitaxelBreast cancerPaclitaxelCandidiasisClotrimazoleVulvovaginal candidiasisClotrimazoleAspergillus infectionClotrimazoleOtitis externaClotrimazolePruritusClotrimazolePityriasis versicolorClotrimazoleBiliary tract cancerTasurgratinibBile duct cancerTasurgratinibSolid tumourTasurgratinibCholangiocarcinomaTasurgratinibBreast cancerTasurgratinibHepatic function declineTasurgratinibLewy body dementiaIoflupane (123I)Diagnostic agentIoflupane (123I)ParkinsonismIoflupane (123I)Alzheimer's diseaseIoflupane (123I)Parkinson's diseaseIoflupane (123I)DementiaIoflupane (123I)晕动病L-Phencynonate HydrochlorideCerebral infarctionL-Phencynonate HydrochlorideVertigoL-Phencynonate Hydrochloride

Source drugs (routes using this intermediate)

DrugTierExpiry
Paclitaxel/Encequidar mesylateTier C — Watch / trade-
Betamethasone/Clotrimazole/Gentamicin SulfateTier C — Watch / trade-
PaclitaxelTier B — Position early-
ClotrimazoleTier C — Watch / trade-
TasurgratinibTier C — Watch / trade-
Ioflupane (123I)Tier C — Watch / trade-
L-Phencynonate HydrochlorideTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Paclitaxel/Encequidar mesylateOptimised routesteps: 3total yield: /
Bromo(phenyl)magnesium→[C11]Benzoic acid→ortho-Phthaloyl chloride→[11C]Benzoyl chloride→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-13-[[(2R,3S)-3-amino-2-hydroxy-3-phenylpropanoyl]oxy]-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
Betamethasone/Clotrimazole/Gentamicin SulfateOptimised routesteps: 3total yield: /
1-Chloranyl-2-methylbenzene→1-Chloro-2-(trichloromethyl)benzene→Benzene→(2-Chlorophenyl) diphenyl chloromethane→Bromo(phenyl)magnesium→1,3-Diaza-2,4-cyclopentadiene→(2-Chlorophenyl)(phenyl)methanone→(2-Chlorophenyl)phenyldichloromethane→(2-Chlorophenyl)-diphenylmethanol→Silver imidazolate
PaclitaxelOptimised routesteps: 3total yield: /
Bromo(phenyl)magnesium→[C11]Benzoic acid→ortho-Phthaloyl chloride→[11C]Benzoyl chloride→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-13-[[(2R,3S)-3-amino-2-hydroxy-3-phenylpropanoyl]oxy]-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
ClotrimazoleOptimised routesteps: 3total yield: /
1-Chloranyl-2-methylbenzene→1-Chloro-2-(trichloromethyl)benzene→Benzene→(2-Chlorophenyl) diphenyl chloromethane→Bromo(phenyl)magnesium→1,3-Diaza-2,4-cyclopentadiene→(2-Chlorophenyl)(phenyl)methanone→(2-Chlorophenyl)phenyldichloromethane→(2-Chlorophenyl)-diphenylmethanol→Silver imidazolate
TasurgratinibOptimised routesteps: 3total yield: /
1-(Phenylmethyl)-4-piperidinone→Bromo(phenyl)magnesium→1-Benzyl-4-phenylpiperidin-4-ol→1-Benzyl-4-phenyl-1,2,3,6-tetrahydropyridine→4-Phenylpiperidine

Intermediates available on this site

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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.