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CAS 102691-36-1
2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidoite3-((bis(diisopropylamino)phosphaneyl)oxy)propanenitrile
Codes: Miltefosine-018, GUAD-007
Application context (from source-drug indications)
利什曼原虫感染Miltefosine皮肤利什曼病MiltefosineChronic urticariaMiltefosine内脏利什曼病Miltefosine粘膜皮肤利什曼病Miltefosine软骨肉瘤Guadecitabine SodiumNon-small cell lung cancerGuadecitabine SodiumMelanomaGuadecitabine SodiumSmall cell lung cancerGuadecitabine SodiumUrothelial carcinomaGuadecitabine SodiumPeritoneal cancerGuadecitabine Sodium
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Miltefosine | Tier C — Watch / trade | - |
| Guadecitabine Sodium | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-Cyano-2-hydroxyethane→2-Cyanoethyl phosphorodichloridoite→Bis(isopropyl)amine→2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidoite→2-Hydroxy-N,N,N-trimethylethan-1-aminium tetraphenylborate(1-)→2-([(2-Cyanoethoxy)[di(propan-2-yl)amino]phosphanyl]oxy)-N,N,N-trimethylethan-1-aminium tetraphenylborate(1-)→1-Hexadecanol
4-amino-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one→4-amino-1-((2R,4S,5R)-4-((trimethylsilyl)oxy)-5-(((trimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-1,3,5-triazin-2(1H)-one→2-phenoxyacetic anhydride→N-(4-oxo-5-((2R,4S,5R)-4-((trimethylsilyl)oxy)-5-(((trimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-4,5-dihydro-1,3,5-triazin-2-yl)-2-phenoxyacetamide→N-(5-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-oxo-4,5-dihydro-1,3,5-triazin-2-yl)-2-phenoxyacetamide→GUAD-006→3-((bis(diisopropylamino)phosphaneyl)oxy)propanenitrile→GUAD-008→GUAD-009→GUAD-010→GUAD-011→GUAD-012
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