宁波优贝德产品网站Unibest
中
Sign in
← Back to patent-cliff list

CAS 105-56-6

ethyl 2-cyanoacetate2-Cyanoacetic acid ethyl ester3-Ethoxy-3-oxopropanenitrile

Codes: TOFA-009, AVAN-034, VONO-003, Folic Acid-070, ETRA-015, Cefoselis Sulfate-012, (II)909096-1-a, PREG-017, PAZU-032, HDM-201-001, TERI-012

Application context (from source-drug indications)

Ankylosing spondylitisTofacitinib CitrateJuvenile rheumatoid arthritisTofacitinib CitrateUlcerative colitisTofacitinib CitratePsoriatic arthritisTofacitinib CitrateRheumatoid arthritisTofacitinib CitrateErectile dysfunctionAvanafilPeptic ulcer bleedingVonoprazan AcetateHelicobacter pylori infectionVonoprazan FumarateOesophagitisVonoprazan FumarateGastro-oesophageal reflux diseaseVonoprazan FumarateHeartburnVonoprazan FumaratePeptic oesophagitisVonoprazan FumarateHelicobacter infectionVonoprazan FumarateEssential hypertensionEnalapril Maleate/Folic AcidHIV infectionEtravirineFriedreich's ataxiaEtravirineInflammatory diseaseEtravirineInsulin resistanceEtravirineBacterial infectionCefoselis SulfateMegaloblastic anaemiaFolic AcidFolate deficiencyFolic AcidNeural tube defectFolic AcidAnaemiaFolic AcidHot flushesFolic AcidHyperhomocysteinaemiaFolic AcidNon-small cell lung cancerIruplinalkibFibromyalgiaPregabalinSeizurePregabalinPostherpetic neuralgiaPregabalin神经痛PregabalinPartial-onset seizurePregabalinDiabetic neuropathyPregabalin肺炎链球菌感染Pazufloxacin MesylateSepsisPazufloxacin MesylateInfectious diseasePazufloxacin MesylateCystitisPazufloxacin Mesylate胆管炎Pazufloxacin MesylateCholecystitisPazufloxacin MesylateSarcomaSiremadlinHaematological malignancySiremadlinHepatic function declineSiremadlinAcute myeloid leukaemiaSiremadlinColorectal cancerSiremadlinMetastatic cancerSiremadlinSystemic lupus erythematosusTeriflunomide Sodium

Source drugs (routes using this intermediate)

DrugTierExpiry
Tofacitinib CitrateTier B — Position early2028
AvanafilTier C — Watch / trade2028
Vonoprazan AcetateTier C — Watch / trade2029
Vonoprazan FumarateTier C — Watch / trade-
Enalapril Maleate/Folic AcidTier C — Watch / trade-
EtravirineTier C — Watch / trade-
Dextran/Calcium Chloride/Potassium Chloride/Sodium Chloride/Sodium lactateTier C — Watch / trade-
Cefoselis SulfateTier C — Watch / trade-
Folic AcidTier C — Watch / trade-
IruplinalkibTier C — Watch / trade-
PregabalinTier B — Position early-
Pazufloxacin MesylateTier C — Watch / trade-
SiremadlinTier C — Watch / trade-
Teriflunomide SodiumTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Tofacitinib CitrateProcess routesteps: 5total yield: 2.08 kg
1-benzyl-N,4-dimethylpiperidin-3-amine→4-chloro-7H-pyrrolo[2,3-d]pyrimidine→N-(1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine→N-methyl-N-(4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine→4-chloro-7-(methylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine→N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7-(methylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine→ethyl 2-cyanoacetate
Tofacitinib CitrateOptimised routesteps: 7total yield: 42.85 g
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine hemi((2R,3R)-2,3-bis((4-methylbenzoyl)oxy)succinate)→2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine→N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-2-chloro-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine→1-benzyl-N,4-dimethylpiperidin-3-amine→N-methyl-N-(4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine→ethyl 2-cyanoacetate→methyl (4-methylpyridin-3-yl)carbamate→1-benzyl-3-((methoxycarbonyl)amino)-4-methylpyridin-1-ium chloride→methyl (1-benzyl-4-methyl-1,2,5,6-tetrahydropyridin-3-yl)carbamate
AvanafilOptimised routesteps: 5total yield: 1.74 g
(S)-pyrrolidin-2-ylmethanol→ethyl (S)-4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)pyrimidine-5-carboxylate→pyrimidin-2-ylmethanamine→ethyl 2-cyanoacetate→urea→ethyl (E)-2-cyano-3-ureidoacrylate→ethyl 6-amino-2-oxo-1,2-dihydropyrimidine-5-carboxylate→2-chloro-4-(chloromethyl)-1-methoxybenzene→ethyl 6-((3-chloro-4-methoxybenzyl)amino)-2-oxo-1,2-dihydropyrimidine-5-carboxylate
Vonoprazan AcetateOriginator routesteps: 10total yield: 912 mg (Vonoprazan Fumarate)
1-(2-fluorophenyl)ethanone→2-bromo-1-(2-fluorophenyl)ethanone→ethyl 2-cyanoacetate→ethyl 2-cyano-4-(2-fluorophenyl)-4-oxobutanoate→ethyl 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→ethyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→(5-(2-fluorophenyl)-1H-pyrrol-3-yl)methanol→5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde→pyridine-3-sulfonyl chloride hydrochloride→5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde→fumaric acid→pyridine-3-sulfonic acid
Vonoprazan FumarateOriginator routesteps: 10total yield: 912 mg
1-(2-fluorophenyl)ethanone→2-bromo-1-(2-fluorophenyl)ethanone→ethyl 2-cyanoacetate→ethyl 2-cyano-4-(2-fluorophenyl)-4-oxobutanoate→ethyl 2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→ethyl 5-(2-fluorophenyl)-1H-pyrrole-3-carboxylate→(5-(2-fluorophenyl)-1H-pyrrol-3-yl)methanol→5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde→pyridine-3-sulfonyl chloride hydrochloride→5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde→fumaric acid→pyridine-3-sulfonic acid

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

SupplierProductPrice bandMOQLead timeQualificationsAction
Unibest Nantong cGMP Site（3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine HCL
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Site4-Chloro-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine
Pharmaceutical Intermediates
On requestOn requestOn request
—
Qualified Partner — East China API Works1-benzyl-4-methylpiperidin-3-one
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP SiteN-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Site5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
Pharmaceutical Intermediates
On requestOn requestOn request
—
Qualified Partner — East China API Works2-chloro-5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP Site5-(2-fluorophenyl)-1H-pyrrole-3-carboxylic acid methyl ester
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Site2-[2-(2-Fluorophenyl)-2-oxoethyl]propanedinitrile
Pharmaceutical Intermediates
On requestOn requestOn request
—
Qualified Partner — East China API Workspyridine-3-sulfonyl chloride
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP Site1H-Pyrrole-3-carboxylic acid, 5-(2-fluorophenyl)-, ethyl ester
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Site5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
Pharmaceutical Intermediates
On requestOn requestOn request
—
Qualified Partner — East China API Works5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Nantong cGMP SiteVonoprazan
Pharmaceutical Intermediates
On requestOn requestOn request
—
Unibest Taizhou GMP-like Site3-Pyridinesulfonyl chloride
Pharmaceutical Intermediates
On requestOn requestOn request
—
Qualified Partner — East China API Works5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehyde
Pharmaceutical Intermediates
On requestOn requestOn request
—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.