CAS 1072-98-6

5-chloropyridin-2-amine

Codes: BETR-002, ETOR-001, AQW-051-001

Application context (from source-drug indications)

Venous thromboembolismBetrixabanHepatic function declineBetrixabanAtrial fibrillationBetrixabanAtrial flutterBetrixabanRenal impairmentBetrixabanThromboembolismBetrixabanOsteoarthritisEtoricoxib痛风性关节炎EtoricoxibDysmenorrhoeaEtoricoxibRheumatoid arthritisEtoricoxibAnkylosing spondylitisEtoricoxibParkinson's diseaseEtoricoxibAnxietyAQW-051表现焦虑AQW-051Alzheimer's diseaseAQW-051Mild cognitive impairmentAQW-051SchizophreniaAQW-051运动障碍AQW-051

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Betrixaban	Tier C — Watch / trade	2028
Etoricoxib	Tier C — Watch / trade	-
AQW-051	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

BetrixabanOriginator routesteps: 4total yield: /

5-methoxy-2-nitrobenzoic acid→5-chloropyridin-2-amine→N-(5-chloropyridin-2-yl)-5-methoxy-2-nitrobenzamide→6-chloro-N-neopentylnicotinamide→4-cyanobenzoyl chloride→N-(5-chloropyridin-2-yl)-2-(4-cyanobenzamido)-5-methoxybenzamide

EtoricoxibOriginator routesteps: 5total yield: /

5-chloropyridin-2-amine→3-bromo-5-chloropyridin-2-amine→(4-(methylthio)phenyl)boronic acid→5-chloro-3-(4-(methylthio)phenyl)pyridin-2-amine→5-chloro-3-(4-(methylsulfonyl)phenyl)pyridin-2-amine→2,5-dichloro-3-(4-(methylsulfonyl)phenyl)pyridine→Borate(1-), triethoxy(6-methyl-3-pyridinyl)-, lithium, (T-4)- (9CI)

AQW-051Originator routesteps: 3total yield: /

AQW-051→5-chloropyridin-2-amine→2-bromo-5-chloropyridine→p-tolylboronic acid→5-chloro-2-(p-tolyl)pyridine→(R)-quinuclidin-3-ol

Intermediates available on this site

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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.