CAS 108-94-1

cyclohexanone4-CyclohexanoneCyclohexanone

Codes: ESKE-006, (II)270899-2-a, DESV-010, Desvenlafaxine-007, ORLI-002, (VI)819152-1-a

Application context (from source-drug indications)

Major depressive disorderEsketamine HydrochlorideSuicidal ideationEsketamine HydrochlorideDepressive disorderEsketamine HydrochlorideAnaesthesiaEsketamine HydrochlorideTreatment-resistant depressionEsketamine HydrochloridePainEsketamine HydrochlorideDepressive disorderDesvenlafaxine Succinate HydrateMajor depressive disorderDesvenlafaxine Succinate HydrateDepressionDesvenlafaxine Succinate HydrateDiabetic neuropathyDesvenlafaxine Succinate HydratePainDesvenlafaxine Succinate HydrateFibromyalgiaDesvenlafaxine Succinate HydrateMajor depressive disorderDesvenlafaxineDepressive disorderDesvenlafaxineObesityOrlistatI型高脂蛋白血症OrlistatHypertriglyceridaemiaOrlistat女性不孕OrlistatDiabetesOrlistatObstructive sleep apnoea syndromeOrlistatHead and neck squamous cell carcinomacRGD-ZW800-1CholangiocarcinomacRGD-ZW800-1Pancreatic cancercRGD-ZW800-1

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Esketamine Hydrochloride	Tier B — Position early	2029
Desvenlafaxine Succinate Hydrate	Tier C — Watch / trade	-
Desvenlafaxine	Tier C — Watch / trade	-
Orlistat	Tier C — Watch / trade	-
cRGD-ZW800-1	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Esketamine HydrochlorideOptimised routesteps: 4total yield: 6.60 mg (Esketamine Hydrochloride)

1-chloro-2-iodobenzene→cyclohexanone→2-(2-chlorophenyl)cyclohexan-1-one→di-tert-butyl (E)-diazene-1,2-dicarboxylate→di-tert-butyl (S)-1-(1-(2-chlorophenyl)-2-oxocyclohexyl)hydrazine-1,2-dicarboxylate→(S)-2-amino-2-(2-chlorophenyl)cyclohexan-1-one

Esketamine HydrochlorideOptimised routesteps: 4total yield: /

1-Chloro-2-iodobenzene→4-Cyclohexanone→2-(2-Chlorophenyl)cyclohexanone→(E)-Di-tert-butyl azodiformate→Di-tert-butyl 1-[(1S)-1-(2-chlorophenyl)-2-oxocyclohexyl]hydrazine-1,2-dicarboxylate→(-)-2(S)-Amino-2-(2-chlorophenyl)cyclohexanone→(1S)-2'-Chloro-1-isocyanato-6-methoxy-1,2,3,4-tetrahydro-1,1'-biphenyl→Formaldehyde→(2S)-2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone

Desvenlafaxine Succinate HydrateOptimised routesteps: 4total yield: 0.43 g

2-(4-hydroxyphenyl)acetic acid→DESV-008→DESV-009→cyclohexanone→DESV-011

Desvenlafaxine Succinate HydrateOptimised routesteps: 5total yield: 6.4 g

DESV-005→4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol→cyclohexanone→2-(4-methoxyphenyl)acetonitrile→2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)acetonitrile→1-(2-amino-1-(4-methoxyphenyl)ethyl)cyclohexanol

Desvenlafaxine Succinate HydrateOptimised routesteps: 4total yield: 82 g

4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol→cyclohexanone→2-(4-methoxyphenyl)acetonitrile→2-(4-hydroxyphenyl)acetonitrile→DESV-021

Intermediates available on this site

No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.