CAS 110-91-8

morpholineDiethylene oximide1-Oxa-4-azacyclohexane

Codes: APIX-012, CARF-022, PEMIGA-027, SOTA-004, COBI-025, Timolol Maleate-007, IXAB-012, (IV) 920279-1-a, (III) 920279-2-a, (II) 920279-3-a, LINE-002, CELE-008 +2 more

Application context (from source-drug indications)

Pulmonary embolismApixabanVenous thrombosisApixabanPaget-Schroetter syndromeApixabanVenous thromboembolismApixabanThrombosisApixabanEmbolismApixabanMultiple myelomaCarfilzomibMyelomaPemigatinibLymphomaPemigatinibBile duct cancerPemigatinibCholangiocarcinomaPemigatinibBiliary tract cancerPemigatinibType 2 diabetesSotagliflozinChronic renal impairmentSotagliflozinHeart failureSotagliflozinHIV infectionCobicistatNon-small cell lung cancerCobicistatAcquired immunodeficiency syndromeCobicistatOcular hypertensionBrimonidine Tartrate/Timolol MaleateGlaucomaBrimonidine Tartrate/Timolol MaleateBreast cancerIxabepiloneMetastatic breast cancerIxabepiloneCervical cancerIxabepiloneProstate cancerIxabepiloneSolid tumourIxabepiloneNeutropeniaIxabepiloneOcular hypertensionBimatoprost/Timolol MaleateOpen-angle glaucomaBimatoprost/Timolol MaleateGlaucomaBimatoprost/Timolol MaleateOcular hypertensionTimolol MaleateGlaucomaTimolol MaleateOpen-angle glaucomaTimolol MaleateTrauma and injuryTimolol MaleateHypertensionTimolol MaleateMigraineTimolol MaleateNon-small cell lung cancerLazertinib MesylateHepatic function declineLazertinib Mesylate非复杂性皮肤和皮肤结构感染LinezolidPneumoniaLinezolidComplicated skin and skin structure infectionLinezolidBacteraemiaLinezolidBacterial infectionLinezolidHealthcare-associated pneumoniaLinezolidPainCelecoxibInflammatory diseaseCelecoxib关节周围炎Celecoxib肌腱炎Celecoxib颈肩腕综合征CelecoxibLow back painCelecoxibChronic renal impairmentMolidustat SodiumAnaemiaMolidustat SodiumKidney diseaseMolidustat SodiumHypercholesterolaemiaAnacetrapibCardiac and vascular disordersAnacetrapibDyslipidaemiaAnacetrapibAtherosclerosisAnacetrapibHyperlipoproteinaemia type IIAnacetrapibHomozygous familial hypercholesterolaemiaAnacetrapib

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Apixaban	Tier A — Act now	2028
Carfilzomib	Tier B — Position early	2029
Pemigatinib	Tier C — Watch / trade	2032
Sotagliflozin	Tier C — Watch / trade	2032
Cobicistat	Tier C — Watch / trade	-
Brimonidine Tartrate/Timolol Maleate	Tier C — Watch / trade	-
Ixabepilone	Tier C — Watch / trade	-
Bimatoprost/Timolol Maleate	Tier C — Watch / trade	-
Timolol Maleate	Tier C — Watch / trade	-
Lazertinib Mesylate	Tier C — Watch / trade	-
Linezolid	Tier B — Position early	-
Celecoxib	Tier B — Position early	-
Molidustat Sodium	Tier C — Watch / trade	-
Anacetrapib	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

ApixabanOptimised routesteps: 6total yield: 1.06 g

1-(4-iodophenyl)piperidin-2-one→ethyl (Z)-2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate→piperidin-2-one→3,3-dichloropiperidin-2-one→3-chloro-5,6-dihydropyridin-2(1H)-one→morpholine→3-morpholino-5,6-dihydropyridin-2(1H)-one→ethyl 1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate→1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid

ApixabanOptimised routesteps: 8total yield: 60.19 g

4-iodoaniline→1-(4-iodophenyl)piperidin-2-one→3,3-dichloro-1-(4-iodophenyl)piperidin-2-one→1-(4-iodophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one→ethyl (Z)-2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate→piperidin-2-one→ethyl 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate→morpholine→5-bromopentanoic acid→5-bromo-N-(4-iodophenyl)pentanamide→3-chloro-1-(4-iodophenyl)-5,6-dihydropyridin-2(1H)-one→3-morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one

CarfilzomibOptimised routesteps: 11total yield: 13.5 g

(tert-butoxycarbonyl)-L-leucine→(S)-2-((tert-butoxycarbonyl)amino)-4-phenylbutanoic acid→((S)-2-(2-morpholinoacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalanine→(S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-aminium 2,2,2-trifluoroacetate→tert-butyl (S)-(1-(methoxy(methyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate→tert-butyl (S)-(2,6-dimethyl-3-oxohept-1-en-4-yl)carbamate→tert-butyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate→(S)-methyl 2-amino-3-phenylpropanoate→methyl (tert-butoxycarbonyl)-L-leucyl-L-phenylalaninate→(S)-1-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-aminium 2,2,2-trifluoroacetate→methyl ((S)-2-((tert-butoxycarbonyl)amino)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate→2-chloroacetyl chloride→methyl ((S)-2-(2-chloroacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate→morpholine→methyl ((S)-2-(2-morpholinoacetamido)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate→N,O-dimethylhydroxylamine hydrochloride→prop-1-en-2-ylmagnesium bromide

PemigatinibOptimised routesteps: 7total yield: /

4-chloro-1H-pyrrolo[2,3-b]pyridine→4-chloro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine→4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde→4-(ethylamino)-1H-pyrrolo[2,3-b]pyridine-5-carbaldehyde→2,6-difluoro-3,5-dimethoxyaniline→5-(((2,6-difluoro-3,5-dimethoxyphenyl)amino)methyl)-N-ethyl-1H-pyrrolo[2,3-b]pyridin-4-amine→3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one→3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-7-(phenylsulfonyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one→3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-2-oxo-7-(phenylsulfonyl)-2,3,4,7-tetrahydro-1H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidine-8-carbaldehyde→morpholine→3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholinomethyl)-7-(phenylsulfonyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one→Pemigatinib

SotagliflozinOriginator routesteps: 11total yield: 67.00 g (Sotagliflozin)

(3S,4R,5S)-tetrahydro-2H-pyran-2,3,4,5-tetraol→(3aS,5S,6R,6aS)-5-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol→(3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxylic acid→morpholine→((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone→1-chloro-2-(4-ethoxybenzyl)-4-iodobenzene→(4-chloro-3-(4-ethoxybenzyl)phenyl)((3aS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanone→(2S,3S,4R,5R,6S)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-2,3,4,5-tetraol→(2R,3S,4R,5S,6S)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)tetrahydro-2H-pyran-2,3,4,5-tetrayl tetraacetate→(2S,3S,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2H-pyran-3,4,5-triyl triacetate→2-chloro-5-iodobenzoic acid→2-chloro-5-iodobenzoyl chloride→ethoxybenzene→(2-chloro-5-iodophenyl)(4-ethoxyphenyl)methanone

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Qualified Partner — East China API Works	3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	3-Morpholino-1-[4-(2-oxopiperidin-1-yl)phenyl]-5,6-dihydropyridin.2(1H)-one Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	1-(4-Methoxyphenyl)-7-0xo-6-[4-(2-0xopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acidethyl ester Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	CarbaMic acid, N-[(1S)-3-Methyl-1-[[(2R)-2-Methyl-2-oxiranyl]carbonyl]butyl]-, 1,1-diMethylethyl ester Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	1-Pentanone, 2-aMino-4-Methyl-1-[(2R)-2-Methyloxiranyl]-, (2S)-, trifluoroacetate (9CI) Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	(alphaS)-alpha-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine methyl ester Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	(alphaS)-alpha-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine methyl ester mono(trifluoroacetate) Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	(alphaS)-alpha-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-L-phenylalanine methyl ester Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	3-phenyl-1H-pyrazole-4-carbaldehyde Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	4-Chloro-2-(methylsulfonyl)pyrimidine Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	4-chloro-N-(2-methoxy-4-morpholino-5-nitrophenyl)pyrimidin-2-amine Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	1-(2-((2-methoxy-4-morpholino-5-nitrophenyl)amino)pyrimidin-4-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)-N-(2-methoxy-4-morpholino-5-nitrophenyl)pyrimidin-2-amine Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	N1-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)-6-methoxy-4-morpholinobenzene-1,3-diamine Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Nantong cGMP Site	L-xylose Pharmaceutical Intermediates	On request	On request	On request	—
Unibest Taizhou GMP-like Site	D-xylo-Pentodialdo-5,2-furanose, 1-C-[4-chloro-3-[(4-ethoxyphenyl)Methyl]phenyl]-4,5-O-(1-Methylethylidene)-,(5S)- Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	((3AS,5R,6S,6aS)-6-hydroxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)(morpholino)methanone Pharmaceutical Intermediates	On request	On request	On request	—

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