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CAS 1117-97-1
N,O-dimethylhydroxylamine
Codes: AVAPR-005, ANAC-022
Application context (from source-drug indications)
Systemic mastocytosisAvapritinibGastrointestinal stromal tumourAvapritinibMast cell leukaemiaAvapritinibHypercholesterolaemiaAnacetrapibCardiac and vascular disordersAnacetrapibDyslipidaemiaAnacetrapibAtherosclerosisAnacetrapibHyperlipoproteinaemia type IIAnacetrapibHomozygous familial hypercholesterolaemiaAnacetrapib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Avapritinib | Tier C — Watch / trade | 2032 |
| Anacetrapib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine→6-bromopyrrolo[2,1-f][1,2,4]triazin-4(3H)-one→1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole→6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one→(S)-1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethan-1-amine→ethyl 2-chloropyrimidine-5-carboxylate→tert-butyl piperazine-1-carboxylate→ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrimidine-5-carboxylate→2-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrimidine-5-carboxylic acid→N,O-dimethylhydroxylamine→tert-butyl 4-(5-(methoxy(methyl)carbamoyl)pyrimidin-2-yl)piperazine-1-carboxylate→(4-fluorophenyl)magnesium bromide→tert-butyl 4-(5-(4-fluorobenzoyl)pyrimidin-2-yl)piperazine-1-carboxylate→(4-fluorophenyl)(2-(piperazin-1-yl)pyrimidin-5-yl)methanone hydrochloride→4-chloro-6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazine→(4-fluorophenyl)(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)methanone→(S)-2-methylpropane-2-sulfinamide→(Z)-N-((4-fluorophenyl)(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)methylene)-2-methylpropane-2-sulfinamide→N-(1-(4-fluorophenyl)-1-(2-(4-(6-(1-methyl-1H-pyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl)piperazin-1-yl)pyrimidin-5-yl)ethyl)-2-methylpropane-2-sulfinamide
2-iodo-4-(trifluoromethyl)aniline→2-amino-5-(trifluoromethyl)benzonitrile→2-iodo-5-(trifluoromethyl)benzonitrile →2-iodo-5-(trifluoromethyl)benzoic acid→[2-iodo-5-(trifluoromethyl)phenyl]methanol →(4S,5R)-5-(3,5-bis(trifluoromethyl)phenyl)-4-methyloxazolidin-2-one→(4-fluoro-5-isopropyl-2-methoxyphenyl)boronic acid→(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol→2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)-1,1'-biphenyl→(S)-2-(((benzyloxy)carbonyl)amino)propanoic acid→N,O-dimethylhydroxylamine→1-bromo-3,5-bis(trifluoromethyl)benzene→1-bromo-3,5-bis(trifluoromethyl)benzene→benzyl (S)-(1-(3,5-bis(trifluoromethyl)phenyl)-1-oxopropan-2-yl)carbamate→benzyl ((1R,2S)-1-(3,5-bis(trifluoromethyl)phenyl)-1-hydroxypropan-2-yl)carbamate
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | Ethyl 2-chloropyrimidine-5-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 1-Methyl-4-pyrazole boronic acid pinacol ester Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.