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CAS 1131-52-8
3-ethoxy-4-methoxybenzaldehyde(3-Ethoxy-4-methoxy-phenyl)-methanone
Codes: APER-001, (XIII)989842-1-b, (XV)989842-2-b
Application context (from source-drug indications)
Plaque psoriasisApremilastBehçet's syndromeApremilastOral ulcerApremilastPsoriasisApremilastPsoriatic arthritisApremilastPlaque psoriasisMufemilastUlcerative colitisMufemilastBehçet's syndromeMufemilastPsoriasisMufemilastChronic obstructive pulmonary diseaseMufemilastAtopic dermatitisMufemilast
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Apremilast | Tier B — Position early | 2028 |
| Mufemilast | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
3-ethoxy-4-methoxybenzaldehyde→1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine→(2S)-2-acetamido-4-methylpentanoic acid→(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine (S)-2-acetamido-4-methylpentanoate→N-(1,3-dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide→3-nitrophthalic acid→3-aminophthalic acid
3-ethoxy-4-methoxybenzaldehyde→1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethan-1-amine→3-nitrophthalic acid→3-ethoxy-4-methoxybenzonitrile→4-nitroisobenzofuran-1,3-dione→2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-4-nitroisoindoline-1,3-dione→4-amino-2-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)isoindoline-1,3-dione
3-ethoxy-4-methoxybenzaldehyde→N-(1,3-dioxo-1,3-dihydroisobenzofuran-4-yl)acetamide→(R)-1-(amino(phenyl)methyl)naphthalen-2-ol→(1R,3S)-3-(3-ethoxy-4-methoxyphenyl)-1-phenyl-2,3-dihydro-1H-naphtho[1,2-e][1,3]oxazine→lithium (methylsulfonyl)methanide→1-((R)-(((S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)amino)(phenyl)methyl)naphthalen-2-ol→(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine
3-ethoxy-4-methoxybenzaldehyde→3-ethoxy-4-methoxybenzonitrile→(S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine→(E)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethenamine→1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanone→(S)-1-phenylethan-1-amine→1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)-N-((S)-1-phenylethyl)ethanamine hydrochloride→(R)-2-methylpropane-2-sulfinamide→(E)-N-(3-ethoxy-4-methoxybenzylidene)-2-methylpropane-2-sulfinamide→N-((S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-2-methylpropane-2-sulfinamide
(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine→3-Hydroxy-4-methoxybenzaldehyde→1-Iodoethane→(3-Ethoxy-4-methoxy-phenyl)-methanone→1,1,1-Trimethyl-N-(trimethylsilyl)silanamine lithium salt→1-(Methylsulfonyl)methane→1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonyl-N-trimethylsilylethanamine→1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine
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