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CAS 118488-18-9
Fmoc-O-tert-butyl-D-tyrosine
Codes: (XX)819152-1-c, (XVI)755707-1-c
Application context (from source-drug indications)
Head and neck squamous cell carcinomacRGD-ZW800-1CholangiocarcinomacRGD-ZW800-1Pancreatic cancercRGD-ZW800-1Cushing's syndrome68Ga-pentixafor醛固酮增多症68Ga-pentixaforSarcoidosis68Ga-pentixaforGraft-versus-host disease68Ga-pentixaforNeuroendocrine tumour68Ga-pentixaforMarginal zone B-cell lymphoma68Ga-pentixafor
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| cRGD-ZW800-1 | Tier C — Watch / trade | - |
| 68Ga-pentixafor | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Resin bound [([[(9H-Fluoren-9-yl)methoxy]carbonyl]amino)acetyl]oxy→Resin bound N-[(2S)-2-[[N6-(tert-butoxycarbonyl)-L-lysyl]oxy]-5-[N'-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]pentanoyl]glycine→Resin bound glycine→(2S)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-5-[2-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]pentanoic acid→Resin bound N5-[N-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidoyl]-L-ornithylglycine→(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid→Fmoc-O-tert-butyl-D-tyrosine→Resin bound (2S)-1-[(carboxymethyl)amino]-1-oxo-5-[N'-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]pentan-2-yl O-tert-butyl-D-tyrosyl-N6-(tert-butoxycarbonyl)-L-lysinate→(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-[(2-methylpropan-2-yl)oxy]-4-oxobutanoic acid→Resin bound (5S,8S,11R,14S)-14-amino-8-[4-[(tert-butoxycarbonyl)amino]butyl]-11-[(4-tert-butoxyphenyl)methyl]-18,18-dimethyl-4,7,10,13,16-pentaoxo-5-[3-[N'-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]propyl]-6,17-dioxa-3,9,12-triazanonadecan-1-oic acid
TCP resin bound (6R,9S,12S)-6-(methylamino)-12-[(naphthalen-2-yl)methyl]-1,7,10,13-tetraoxo-9-[3-[N'-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]propyl]-1-[4-([2-[4,7,10-tris(2-tert-butoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetamido]methyl)phenyl]-2,8,11,14-tetraazahexadecan-16-oic acid→Fmoc-O-tert-butyl-D-tyrosine→TCP resin bound (5R,8R,11S,14S)-5-[(4-tert-butoxyphenyl)methyl]-1-(9H-fluoren-9-yl)-7-methyl-14-[(naphthalen-2-yl)methyl]-3,6,9,12,15-pentaoxo-11-[3-[N'-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]propyl]-8-[3-[4-([2-[4,7,10-tris(2-tert-butoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetamido]methyl)benzamido]propyl]-2-oxa-4,7,10,13,16-pentaazaoctadecan-18-oic acid→TCP resin bound (6R,9S,12S)-6-[[(2R)-2-amino-3-(4-tert-butoxyphenyl)propanoyl](methyl)amino]-12-[(naphthalen-2-yl)methyl]-1,7,10,13-tetraoxo-9-[3-[N'-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]propyl]-1-[4-([2-[4,7,10-tris(2-tert-butoxy-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl]acetamido]methyl)phenyl]-2,8,11,14-tetraazahexadecan-16-oic acid
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