CAS 123-62-6

propionic anhydrideMethylacetic anhydride

Codes: PARE-005, (IIc)471701-2-a, EMOX-002

Application context (from source-drug indications)

Postoperative painParecoxib Sodium神经疾病Parecoxib Sodium肩部疼痛Parecoxib SodiumInfluenza virus infectionNorketotifenAllergic conjunctivitisNorketotifenAllergic rhinitisNorketotifenIschaemic strokeEthylmethylhydroxypyridine SuccinateOpen-angle glaucomaEthylmethylhydroxypyridine SuccinateAnxiety disorderEthylmethylhydroxypyridine SuccinateAttention deficit hyperactivity disorderEthylmethylhydroxypyridine Succinate脑缺血Ethylmethylhydroxypyridine Succinate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Parecoxib Sodium	Tier C — Watch / trade	-
Norketotifen	Tier C — Watch / trade	-
Ethylmethylhydroxypyridine Succinate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Parecoxib SodiumOriginator routesteps: 5total yield: 12.2 g

1,2-diphenylethan-1-one→(E)-1,2-diphenylethan-1-one oxime→5-methyl-3,4-diphenyl-4,5-dihydroisoxazol-5-ol→4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide→propionic anhydride→N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)propionamide

Parecoxib SodiumOptimised routesteps: 7total yield: 9.11 g

1,2-diphenylethan-1-one→5-methyl-3,4-diphenyl-4,5-dihydroisoxazol-5-ol→4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide→propionic anhydride→N-((4-(5-methyl-3-phenylisoxazol-4-yl)phenyl)sulfonyl)propionamide→(Z)-1-(1,2-diphenylvinyl)pyrrolidine→(Z)-3,4-diphenyl-4-(pyrrolidin-1-yl)but-3-en-2-one→5-methyl-3,4-diphenylisoxazole

Parecoxib SodiumOptimised routesteps: 5total yield: 11.9 g

1,2-diphenylethan-1-one→4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonamide→propionic anhydride→4-(2-oxo-2-phenylethyl)benzenesulfonic acid→4-(1,3-dioxo-1-phenylbutan-2-yl)benzenesulfonic acid→4-(5-methyl-3-phenylisoxazol-4-yl)benzenesulfonic acid

NorketotifenOptimised routesteps: 2total yield: /

4-(1-Methyl-4-piperidinylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one→Acetic acid acetic anhydride→Dicarbonic acid diethyl diester→Methylacetic anhydride→Benzoic acid anhydride→Dibenzyl dicarbonate→Butanoic acid 1-oxobutyl ester→4-(1-Acetylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one→4-[8-Oxo-6-thiatricyclo[8.4.0.0(3,7)]tetradeca-1(14),3(7),4,10,12-pentaen-2-ylidene]piperidine-1-carboxylic acid ethyl ester→4-(1-Propanoylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one→4-(1-Benzoylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one→Benzyl 4-(10-oxo-9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)piperidine-1-carboxylate→4-(1-Butanoylpiperidin-4-ylidene)-4,9-dihydro-10H-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one

Ethylmethylhydroxypyridine SuccinateOriginator routesteps: 2total yield: 30 g

2-methylfuran→propionic anhydride→1-(5-methylfuran-2-yl)propan-1-one

Intermediates available on this site

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Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Nantong cGMP Site	5-Methyl-3,4-diphenylisoxazole Pharmaceutical Intermediates	On request	On request	On request	—

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