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CAS 2295-31-0

thiazolidine-2,4-dione

Codes: LOBE-008, PIOG-012, HYPIL-008

Application context (from source-drug indications)

Type 2 diabetesLobeglitazone SulfateGastroparesisLobeglitazone SulfateRenal impairmentLobeglitazone SulfateAbnormal liver functionLobeglitazone SulfateType 2 diabetesAlogliptin Benzoate/Pioglitazone HydrochlorideType 2 diabetesPioglitazone HydrochloridePulmonary hypertensionPioglitazone HydrochlorideBreast cancerPioglitazone HydrochlorideNon-alcoholic steatohepatitisPioglitazone HydrochlorideCocaine addictionPioglitazone HydrochlorideAlcohol abusePioglitazone Hydrochloride肾上腺脑白质营养不良LeriglitazoneFriedreich's ataxiaLeriglitazone

Source drugs (routes using this intermediate)

DrugTierExpiry
Lobeglitazone SulfateTier C — Watch / trade-
Alogliptin Benzoate/Pioglitazone HydrochlorideTier C — Watch / trade-
Pioglitazone HydrochlorideTier B — Position early-
LeriglitazoneTier C — Watch / trade-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Lobeglitazone SulfateOriginator routesteps: 6total yield: 2.03 g
4,6-dichloropyrimidine→4-methoxyphenol→4-chloro-6-(4-methoxyphenoxy)pyrimidine→2-(methylamino)ethan-1-ol→2-((6-(4-methoxyphenoxy)pyrimidin-4-yl)(methyl)amino)ethanol→4-fluorobenzaldehyde→4-(2-((6-(4-methoxyphenoxy)pyrimidin-4-yl)(methyl)amino)ethoxy)benzaldehyde→thiazolidine-2,4-dione→(Z)-5-(4-(2-((6-(4-methoxyphenoxy)pyrimidin-4-yl)(methyl)amino)ethoxy)benzylidene)thiazolidine-2,4-dione
Alogliptin Benzoate/Pioglitazone HydrochlorideOptimised routesteps: 4total yield: 0.65 g
2-(5-ethylpyridin-2-yl)ethan-1-ol→4-fluorobenzonitrile→4-(2-(5-ethylpyridin-2-yl)ethoxy)benzonitrile→4-(2-(5-ethylpyridin-2-yl)ethoxy)benzaldehyde→thiazolidine-2,4-dione→(Z)-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione
Alogliptin Benzoate/Pioglitazone HydrochlorideOptimised routesteps: 5total yield: 49.60 kg
2-(5-ethylpyridin-2-yl)ethan-1-ol→4-(2-(5-ethylpyridin-2-yl)ethoxy)benzaldehyde→thiazolidine-2,4-dione→(Z)-5-(4-(2-(5-ethylpyridin-2-yl)ethoxy)benzylidene)thiazolidine-2,4-dione→2-(5-ethylpyridin-2-yl)ethyl methanesulfonate→4-hydroxybenzaldehyde
Alogliptin Benzoate/Pioglitazone HydrochlorideOptimised routesteps: 7total yield: 1.10 g
thiazolidine-2,4-dione→4-hydroxybenzaldehyde→5-ethyl-2-vinylpyridine→2-bromo-1-(5-ethylpyridin-2-yl)ethan-1-ol→4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzaldehyde→(Z)-5-(4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzylidene)thiazolidine-2,4-dione→5-(4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzyl)thiazolidine-2,4-dione→5-(4-(2-chloro-2-(5-ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione
Alogliptin Benzoate/Pioglitazone HydrochlorideOptimised routesteps: 9total yield: 0.04 g
2-(5-ethylpyridin-2-yl)ethan-1-ol→thiazolidine-2,4-dione→4-hydroxybenzaldehyde→4-(2-(5-ethylpyridin-2-yl)-2-hydroxyethoxy)benzaldehyde→5-ethyl-2-(2-hydroxyethyl)pyridine 1-oxide→1-(5-ethylpyridin-2-yl)ethane-1,2-diyl diacetate→1-(5-ethylpyridin-2-yl)ethane-1,2-diol→4-(5-ethylpyridin-2-yl)-1,3,2-dioxathiolane 2-oxide→1-(5-ethylpyridin-2-yl)-2-(4-formylphenoxy)ethyl 4-methylbenzenesulfonate→(Z)-2-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-1-(5-ethylpyridin-2-yl)ethyl 4-methylbenzenesulfonate→2-(4-((2,4-dioxothiazolidin-5-yl)methyl)phenoxy)-1-(5-ethylpyridin-2-yl)ethyl 4-methylbenzenesulfonate

Intermediates available on this site

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This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.