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CAS 4530-20-5
2-((tert-Butoxycarbonyl)amino)acetic acid2-((tert-butoxycarbonyl)amino)acetic acid
Codes: (XVIb)700647-1-b, (VIb)1062329-1-a, FIRT-003
Application context (from source-drug indications)
蠕形螨性睑缘炎Lotilaner螨虫感染Lotilaner莱姆病LotilanerRosaceaLotilaner睑板腺功能障碍LotilanerColorectal cancerFirtecan pegolBreast cancerFirtecan pegolSolid tumourFirtecan pegolMetastatic breast cancerFirtecan pegolLymphomaFirtecan pegol
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Lotilaner | Tier C — Watch / trade | - |
| Dazdotuftide | Tier C — Watch / trade | - |
| Firtecan pegol | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride→2,5-Dioxo-3-oxazolidinecarboxylic acid 1,1-dimethylethyl ester→2-(Benzyloxycarbonylamino)acetic acid→2-((tert-Butoxycarbonyl)amino)acetic acid→2-Amino-1,1,1-trifluoroethane hydrochloride→2-Amino-1,1,1-trifluoroethane→Benzyl [2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]carbamate→[(2,2,2-Trifluoroethylcarbamoyl)methyl]carbamic acid tert-butyl ester→2-Chloranylethanoyl chloride→2-Chloro-N-(2,2,2-trifluoroethyl)acetamide→(N-Benzylaminomethyl)benzene→2-(Dibenzylamino)-N-(2,2,2-trifluoroethyl)acetamide
4-Aminophenyl 2-(trimethylammonio)ethyl phosphate→4-Diazoniophenyl 2-(trimethylazaniumyl)ethyl phosphate chloride→(2S)-3-(4-Hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid→N-[[(9H-Fluoren-9-yl)methoxy]carbonyl]-3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]-L-tyrosine→N-(tert-Butoxycarbonyl)-3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]-L-tyrosine→Resin bound 3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]-L-tyrosine→2-(9H-Fluoren-9-ylmethoxycarbonylamino)acetic acid→2-((tert-Butoxycarbonyl)amino)acetic acid→Resin bound glycyl-3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]-L-tyrosine→(2S)-2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-5-[2-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidamido]pentanoic acid→(2S)-2-{[(tert-Butoxy)carbonyl]amino}-5-{N'-[(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)sulfonyl]carbamimidamido}pentanoic acid→Resin bound N5-[N-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-sulfonyl)carbamimidoyl]-L-ornithylglycyl-3-[(E)-[4-([[2-(trimethylazaniumyl)ethoxy]phosphinato]oxy)phenyl]diazenyl]-L-tyrosine
(S)-4,11-diethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione→(S)-9-((tert-butyldiphenylsilyl)oxy)-4,11-diethyl-4-hydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione→2-((tert-butoxycarbonyl)amino)acetic acid→(S)-9-((tert-butyldiphenylsilyl)oxy)-4,11-diethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl (tert-butoxycarbonyl)glycinate→(S)-9-((tert-butyldiphenylsilyl)oxy)-4,11-diethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl glycinate hydrochloride→tert-butyl 2-bromoacetate→7,7'-(oxybis(methylene))bis(3,6,9,12-tetraoxatetradecanedioic acid)→tetrakis((S)-9-((tert-butyldiphenylsilyl)oxy)-4,11-diethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl) 10,10'-(oxybis(methylene))bis(4,17-dioxo-6,9,12,15-tetraoxa-3,18-diazaicosanedioate)→2,2',2'',2'''-((oxybis(propane-3,1,2-triyl))tetrakis(oxy))tetrakis(ethan-1-ol)→tetra-tert-butyl 7,7'-(oxybis(methylene))bis(3,6,9,12-tetraoxatetradecanedioate)
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 2-bromo-3-methyl-5-acetylthiophene Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | methyl 5-acetyl-3-methylthiophene-2-carboxylate Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 5-acetyl-3-methyl-2-Thiophenecarboxylic acid Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.