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CAS 629-03-8
1,6-dibromohexane
Codes: SALM-001, VILA-003
Application context (from source-drug indications)
AsthmaBudesonide/Salmeterol xinafoateChronic obstructive pulmonary diseaseSalmeterol xinafoateAsthmaSalmeterol xinafoateExercise-induced asthmaSalmeterol xinafoateBronchospasmSalmeterol xinafoateSubmental fat accumulationSalmeterol xinafoateAsthmaVilanterol TrifenatateChronic obstructive pulmonary diseaseVilanterol Trifenatate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Budesonide/Salmeterol xinafoate | Tier C — Watch / trade | - |
| Salmeterol xinafoate | Tier C — Watch / trade | - |
| Vilanterol Trifenatate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1,6-dibromohexane→4-phenylbutan-1-ol→(4-((6-bromohexyl)oxy)butyl)benzene→2,2-dimethoxyethanamine→N-(2,2-dimethoxyethyl)-6-(4-phenylbutoxy)hexan-1-amine→benzyl (2,2-dimethoxyethyl)(6-(4-phenylbutoxy)hexyl)carbamate→benzyl (2-oxoethyl)(6-(4-phenylbutoxy)hexyl)carbamate→6-bromo-2,2-dimethyl-4H-benzo[d][1,3]dioxine→benzyl (2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-hydroxyethyl)(6-(4-phenylbutoxy)hexyl)carbamate→1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-((6-(4-phenylbutoxy)hexyl)amino)ethanol→4-bromo-2-(hydroxymethyl)phenol
1,6-dibromohexane→4-phenylbutan-1-ol→(4-((6-bromohexyl)oxy)butyl)benzene→N-benzyl-6-(4-phenylbutoxy)hexan-1-amine hydrochloride→methyl 2-(benzyloxy)-5-(2-bromoacetyl)benzoate→methyl 5-(2-(benzyl(6-(4-phenylbutoxy)hexyl)amino)acetyl)-2-(benzyloxy)benzoate→2-(benzyl(6-(4-phenylbutoxy)hexyl)amino)-1-(4-(benzyloxy)-3-(hydroxymethyl)phenyl)ethanol→methyl 5-acetyl-2-hydroxybenzoate→methyl 5-acetyl-2-(benzyloxy)benzoate
1,6-dibromohexane→4-phenylbutan-1-ol→(4-((6-bromohexyl)oxy)butyl)benzene→2,2-dimethoxyethanamine→N-(2,2-dimethoxyethyl)-6-(4-phenylbutoxy)hexan-1-amine→benzyl (2,2-dimethoxyethyl)(6-(4-phenylbutoxy)hexyl)carbamate→benzyl (2-oxoethyl)(6-(4-phenylbutoxy)hexyl)carbamate→6-bromo-2,2-dimethyl-4H-benzo[d][1,3]dioxine→benzyl (2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-hydroxyethyl)(6-(4-phenylbutoxy)hexyl)carbamate→1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-((6-(4-phenylbutoxy)hexyl)amino)ethanol→4-bromo-2-(hydroxymethyl)phenol
1,6-dibromohexane→4-phenylbutan-1-ol→(4-((6-bromohexyl)oxy)butyl)benzene→N-benzyl-6-(4-phenylbutoxy)hexan-1-amine hydrochloride→methyl 2-(benzyloxy)-5-(2-bromoacetyl)benzoate→methyl 5-(2-(benzyl(6-(4-phenylbutoxy)hexyl)amino)acetyl)-2-(benzyloxy)benzoate→2-(benzyl(6-(4-phenylbutoxy)hexyl)amino)-1-(4-(benzyloxy)-3-(hydroxymethyl)phenyl)ethanol→methyl 5-acetyl-2-hydroxybenzoate→methyl 5-acetyl-2-(benzyloxy)benzoate
N-methoxy-N-methylacetamide→1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethan-1-one→2-bromo-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethan-1-one→VILA-014→tert-butyl (2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-oxoethyl)carbamate→tert-butyl (R)-(2-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-hydroxyethyl)carbamate→2-(bromomethyl)-1,3-dichlorobenzene→2-((2,6-dichlorobenzyl)oxy)ethan-1-ol→1,6-dibromohexane→2-((2-((6-bromohexyl)oxy)ethoxy)methyl)-1,3-dichlorobenzene→(R)-5-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one→(R)-3-(6-(2-((2,6-dichlorobenzyl)oxy)ethoxy)hexyl)-5-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)oxazolidin-2-one→(R)-2-((6-(2-((2,6-dichlorobenzyl)oxy)ethoxy)hexyl)amino)-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethan-1-ol→2,2,2-triphenylacetic acid→4-bromo-2-(hydroxymethyl)phenol→6-bromo-2,2-dimethyl-4H-benzo[d][1,3]dioxine
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