CAS 66-22-8

pyrimidine-2,4(1H,3H)-dione2,4(1H,3H)-Pyrimidinedione2,4-Dihydroxypyrimidine1,2,3,4-Tetrahydropyrimidine-2,4-dione

Codes: DASA-019, Molnupiravir-036, (I)229059-10-a

Application context (from source-drug indications)

Chronic hepatitis CDasabuvir Sodium HydrateHepatitis CDasabuvir Sodium HydrateDecompensated cirrhosisDasabuvir Sodium HydrateRenal impairmentDasabuvir Sodium HydrateFibrosisDasabuvir Sodium HydrateEnd-stage renal diseaseDasabuvir Sodium HydrateCOVID-19Molnupiravir呼吸道合胞体病毒感染MolnupiravirInfluenza virus infectionMolnupiravirRenal impairmentMolnupiravirHepatic function declineMolnupiravir巨细胞病毒感染Vidarabine MonophosphateHerpesvirus infectionVidarabine Monophosphate

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Dasabuvir Sodium Hydrate	Tier C — Watch / trade	-
Molnupiravir	Tier B — Position early	-
Vidarabine Monophosphate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Dasabuvir Sodium HydrateOptimised routesteps: 4total yield: 20.74 g

2-(tert-butyl)phenol→N-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-2-yl)methanesulfonamide→2-(tert-butyl)-4,6-diiodophenol→1-(tert-butyl)-3,5-diiodo-2-methoxybenzene→pyrimidine-2,4(1H,3H)-dione→1-(3-(tert-butyl)-5-iodo-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione

Dasabuvir Sodium HydrateOptimised routesteps: 7total yield: 30.7 g

2-(tert-butyl)phenol→2-(tert-butyl)-4,6-diiodophenol→1-(tert-butyl)-3,5-diiodo-2-methoxybenzene→pyrimidine-2,4(1H,3H)-dione→1-(3-(tert-butyl)-5-iodo-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione→(6-hydroxynaphthalen-2-yl)boronic acid→1-(3-(tert-butyl)-5-(6-hydroxynaphthalen-2-yl)-4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione→6-[3-Tert-Butyl-5-(2,4-Dioxo-3,4-Dihydropyrimidin-1(2H)-Yl)-2-Methoxyphenyl]-2-Naphthyl 1,1,2,2,3,3,4,4,4-Nonafluorobutane-1-Sulfonate→methanesulfonamide

MolnupiravirOptimised routesteps: 6total yield: 3.5g(Molnupiravir-031)

2,4(1H,3H)-Pyrimidinedione→D-Ribofuranose 1,2,3,5-tetraacetate→Triacetyl uridine→4-Chloro-1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)pyrimidin-2(1H)-one→2',3',5'-Tri-O-acetyl-N-hydroxycytidine→N4-Hydroxycytidine

MolnupiravirOptimised routesteps: 3total yield: /

5-O-(2-Methylpropanoyl)-D-ribofuranose→Molnupiravir-012→alpha-Methylpropionic anhydride→2,4-Dihydroxypyrimidine→5'-O-(2-Methylpropanoyl)uridine

MolnupiravirOptimised routesteps: 1total yield: /

Molnupiravir-052→2,4(1H,3H)-Pyrimidinedione→1-(beta-D-Ribofuranosyl)uracil

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Taizhou GMP-like Site	((3aR,4R,6R,6aR)-6-(4-(hydroxyamino)-2-oxopyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.