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CAS 687-47-8
ethyl (S)-2-hydroxypropanoate
Codes: POSA-023, APITO-009
Application context (from source-drug indications)
CandidiasisPosaconazoleAspergillus infectionPosaconazoleFungal infectionPosaconazoleOral candidiasisPosaconazoleCoccidioidomycosisPosaconazoleHistoplasmosisPosaconazoleProstate cancerApitolisibBreast cancerApitolisibSolid tumourApitolisibRenal cell carcinomaApitolisibNon-Hodgkin lymphomaApitolisibEndometrial cancerApitolisib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Posaconazole | Tier C — Watch / trade | - |
| Apitolisib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)aniline→phenyl carbonochloridate→phenyl (4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)carbamate→ethyl (S)-2-hydroxypropanoate→pyrrolidine→(S)-2-hydroxy-1-(pyrrolidin-1-yl)propan-1-one→(S)-2-(benzyloxy)-1-(pyrrolidin-1-yl)propan-1-one→(S)-2-(benzyloxy)pentan-3-one→(2S)-2-(benzyloxy)pentan-3-ol→1-chloro-4-(methylsulfonyl)benzene→(2S)-2-(benzyloxy)pentan-3-yl 4-chlorobenzenesulfonate→((2S,3S)-2-(benzyloxy)pentan-3-yl)hydrazine (2R,3R)-2,3-bis(benzoyloxy)succinate→N'-((2S,3S)-2-(benzyloxy)pentan-3-yl)formohydrazide→4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-2-((2S,3S)-2-(benzyloxy)pentan-3-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one→POSA-034→4-(4-(4-aminophenyl)piperazin-1-yl)phenol
methyl 3-amino-4-methylthiophene-2-carboxylate→7-methylthieno[3,2-d]pyrimidine-2,4(1H,3H)-dione→2,4-dichloro-7-methylthieno[3,2-d]pyrimidine→4-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)morpholine→2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde→(S)-2-hydroxy-1-(piperazin-1-yl)propan-1-one oxalate→(S)-1-(4-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one→(2-aminopyrimidin-5-yl)boronic acid→ethyl (S)-2-hydroxypropanoate→(S)-2-hydroxy-1-(piperazin-1-yl)propan-1-one→5-bromopyrimidin-2-amine→APITO-012
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