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CAS 68858-20-8
(((9H-fluoren-9-yl)methoxy)carbonyl)-L-valine(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoic acid
Codes: ROMI-043, (VI) 847759-1-a
Application context (from source-drug indications)
Peripheral T-cell lymphomaRomidepsinLymphomaRomidepsinPhaeochromocytomaRomidepsinCutaneous T-cell lymphomaRomidepsinNon-Hodgkin lymphomaRomidepsinMelanomaRomidepsinMetastatic breast cancerLutetium (177Lu) zaregreptide dizuxetanBreast cancerLutetium (177Lu) zaregreptide dizuxetanNeoplasmLutetium (177Lu) zaregreptide dizuxetanProstate cancerLutetium (177Lu) zaregreptide dizuxetanNeuroendocrine carcinomaLutetium (177Lu) zaregreptide dizuxetanSolid tumourLutetium (177Lu) zaregreptide dizuxetan
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Romidepsin | Tier C — Watch / trade | - |
| Lutetium (177Lu) zaregreptide dizuxetan | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
methyl N-(((9H-fluoren-9-yl)methoxy)carbonyl)-S-trityl-D-cysteinyl-L-threonyl-L-valinate→(3S,9S,12R,16S,Z)-6-ethylidene-3,12-diisopropyl-16-((E)-4-(tritylthio)but-1-en-1-yl)-9-((tritylthio)methyl)-1-oxa-4,7,10,13-tetraazacyclohexadecane-2,5,8,11,14-pentaone→ROMI-034→N-(((9H-fluoren-9-yl)methoxy)carbonyl)-S-trityl-D-cysteine→methyl N-(((9H-fluoren-9-yl)methoxy)carbonyl)-S-trityl-D-cysteinyl-L-threoninate→methyl (Z)-2-((S)-2-((R)-2-amino-3-methylbutanamido)-3-(tritylthio)propanamido)but-2-enoate→(5R,8S,Z)-11-ethylidene-1-(9H-fluoren-9-yl)-5-isopropyl-3,6,9-trioxo-8-((tritylthio)methyl)-2-oxa-4,7,10-triazadodecan-12-oic acid→ROMI-041→ROMI-042→(((9H-fluoren-9-yl)methoxy)carbonyl)-L-valine
(2S)-2-({[(9H-Fluoren-9-yl)methoxy]carbonyl}amino)-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanoic acid→Resin bound N-[[(9H-fluoren-9-yl)methoxy]carbonyl]-1-(triphenylmethyl)-L-histidine→Resin bound 1-(triphenylmethyl)-L-histidine→2-(9H-Fluoren-9-ylmethoxycarbonylamino)acetic acid→Resin bound glycyl-1-(triphenylmethyl)-L-histidine→(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoic acid→Resin bound L-valylglycyl-1-(triphenylmethyl)-L-histidine→(2S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)propanoic acid→Resin bound L-alanyl-L-valylglycyl-1-(triphenylmethyl)-L-histidine→(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-(tert-butoxycarbonyl)-1H-indol-3-yl)propanoic acid→Resin bound 1-(tert-butoxycarbonyl)-L-tryptophyl-L-alanyl-L-valylglycyl-1-(triphenylmethyl)-L-histidine
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