(S)-2-amino-3-methylbutanoic acid (72-18-4) intermediate

Application context (from source-drug indications)

HypertensionLevamlodipine Besylate/ValsartanEssential hypertensionLevamlodipine Besylate/ValsartanEssential hypertensionValsartan/Amlodipine OrotateEssential hypertensionValsartan/Lercanidipine HydrochlorideLeft ventricular dysfunctionValsartanHypertensionValsartanEssential hypertensionValsartanPulmonary arterial hypertensionValsartanRight ventricular dysfunctionValsartanPost-myocardial infarction syndromeValsartan分离性焦虑R-fluoxetineAnxietyR-fluoxetineAnxiety disorderR-fluoxetine

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Levamlodipine Besylate/Valsartan	Tier C — Watch / trade	-
Valsartan/Amlodipine Orotate	Tier C — Watch / trade	-
Valsartan/Lercanidipine Hydrochloride	Tier C — Watch / trade	-
Valsartan	Tier B — Position early	-
R-fluoxetine	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Levamlodipine Besylate/ValsartanOptimised routesteps: 3total yield: /

2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-carbaldehyde→(S)-2-amino-3-methylbutanoic acid→(S,Z)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methylene)amino)-3-methylbutanoic acid→(S)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoic acid

Valsartan/Amlodipine OrotateOptimised routesteps: 3total yield: /

2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-carbaldehyde→(S)-2-amino-3-methylbutanoic acid→(S,Z)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methylene)amino)-3-methylbutanoic acid→(S)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoic acid

Valsartan/Lercanidipine HydrochlorideOptimised routesteps: 3total yield: /

2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-carbaldehyde→(S)-2-amino-3-methylbutanoic acid→(S,Z)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methylene)amino)-3-methylbutanoic acid→(S)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoic acid

ValsartanOptimised routesteps: 3total yield: /

2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-carbaldehyde→(S)-2-amino-3-methylbutanoic acid→(S,Z)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methylene)amino)-3-methylbutanoic acid→(S)-2-(((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-methylbutanoic acid

R-fluoxetineOriginator routesteps: 10total yield: 0.49 g (R-fluoxetine)

(S)-2-amino-3-methylbutanoic acid→(tert-butoxycarbonyl)-L-valine→(R)-1-phenylethan-1-amine→tert-butyl ((S)-3-methyl-1-oxo-1-(((R)-1-phenylethyl)amino)butan-2-yl)carbamate→(S)-2-amino-3-methyl-N-((R)-1-phenylethyl)butanamide→(S)-3-methyl-N1-((R)-1-phenylethyl)butane-1,2-diamine→(S)-4-isopropyl-1-((R)-1-phenylethyl)imidazolidin-2-one→(S)-3-acetyl-4-isopropyl-1-((R)-1-phenylethyl)imidazolidin-2-one→(S)-3-((R)-3-hydroxy-3-phenylpropanoyl)-4-isopropyl-1-((R)-1-phenylethyl)imidazolidin-2-one→(R)-3-hydroxy-N-methyl-3-phenylpropanamide→(R)-3-(methylamino)-1-phenylpropan-1-ol→1-fluoro-4-(trifluoromethyl)benzene→R-fluoxetine

Intermediates available on this site

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