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CAS 75-36-5
Acetic acid chlorideacetyl chloride
Codes: (XXII)101438-72-c, (Xb)989842-1-a, (Vb)989842-2-a, ANAC-029
Application context (from source-drug indications)
Breast cancerPaclitaxel/Encequidar mesylateAdenocarcinomaPaclitaxel/Encequidar mesylateAngiosarcomaPaclitaxel/Encequidar mesylateSolid tumourPaclitaxel/Encequidar mesylatePancreatic cancerPaclitaxelNon-small cell lung cancerPaclitaxelHodgkin's diseasePaclitaxelSeminomaPaclitaxelOvarian cancerPaclitaxelBreast cancerPaclitaxelPlaque psoriasisMufemilastUlcerative colitisMufemilastBehçet's syndromeMufemilastPsoriasisMufemilastChronic obstructive pulmonary diseaseMufemilastAtopic dermatitisMufemilastHypercholesterolaemiaAnacetrapibCardiac and vascular disordersAnacetrapibDyslipidaemiaAnacetrapibAtherosclerosisAnacetrapibHyperlipoproteinaemia type IIAnacetrapibHomozygous familial hypercholesterolaemiaAnacetrapib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Paclitaxel/Encequidar mesylate | Tier C — Watch / trade | - |
| Paclitaxel | Tier B — Position early | - |
| Mufemilast | Tier C — Watch / trade | - |
| Anacetrapib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-Bis(acetyloxy)-1,15-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate→(2alpha,5alpha,7beta,10beta,13alpha)-10-(Acetyloxy)-5-bromo-1-hydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]taxa-4(20),11-dien-2-yl benzoate→(2alpha,5alpha,7beta,10beta,13alpha)-10-(Acetyloxy)-5-bromo-1,4,20-trihydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]tax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-10-(Acetyloxy)-1,4-dihydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]-5,20-epoxytax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-1-hydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]-5,20-epoxytax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-1,7,13-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate→Acetic acid chloride
(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-Bis(acetyloxy)-1,15-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate→(2alpha,5alpha,7beta,10beta,13alpha)-10-(Acetyloxy)-5-bromo-1-hydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]taxa-4(20),11-dien-2-yl benzoate→(2alpha,5alpha,7beta,10beta,13alpha)-10-(Acetyloxy)-5-bromo-1,4,20-trihydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]tax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-10-(Acetyloxy)-1,4-dihydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]-5,20-epoxytax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-1-hydroxy-9-oxo-7,13-bis[(triethylsilyl)oxy]-5,20-epoxytax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-1,7,13-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate→Acetic acid chloride
3,4-Bis(bromanyl)thiophene→3,4-Dicyanothiophene→Thiophene-3,4-dicarboxylic acid→1H,3H-Thieno[3,4-c]furan-1,3-dione→2-Nitrothiophene-3,4-dicarboxylic acid→4-Nitro-1H,3H-thieno[3,4-c]furan-1,3-dione→(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine→3-Nitro-5-[1(S)-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]thieno[3,4-c]pyrrole-4,6-dione→1-Amino-5-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)ethyl]-4H-thieno[3,4-c]pyrrole-4,6(5H)-dione→Acetic acid acetic anhydride→Acetic acid chloride
3-tert-Butyl 4-methyl 2-aminothiophene-3,4-dicarboxylate→3-Benzyl 4-methyl 2-aminothiophene-3,4-dicarboxylate→2-Amino-4-(methoxycarbonyl)thiophene-3-carboxylic acid→(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine→Methyl 5-amino-4-[[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)ethyl]carbamoyl]thiophene-3-carboxylate→Acetic acid acetic anhydride→Acetic acid chloride→Methyl 5-acetamido-4-[[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)ethyl]carbamoyl]thiophene-3-carboxylate→5-Acetamido-4-[[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)ethyl]carbamoyl]thiophene-3-carboxylic acid
1-bromo-4-fluoro-5-isopropyl-2-methoxybenzene→(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)methanol→2'-(chloromethyl)-4-fluoro-5-isopropyl-2-methoxy-4'-(trifluoromethyl)-1,1'-biphenyl→1-bromo-2,4-difluorobenzene→1-bromo-4-fluoro-2-methoxybenzene→acetyl chloride→1-(5-bromo-2-fluoro-4-methoxyphenyl)ethan-1-one→2-(5-bromo-2-fluoro-4-methoxyphenyl)propan-2-ol→2-(3-(trifluoromethyl)phenyl)-4,5-dihydrooxazole→2-(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)-4,5-dihydrooxazole→methyl carbonochloridate→methyl (2-chloroethyl)(4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)-[1,1'-biphenyl]-2-carbonyl)carbamate
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