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CAS 88-65-3
2-Bromobenzoic acid2-bromobenzoic acid
Codes: Tolfenamic Acid-005, DA-8010-001
Application context (from source-drug indications)
ArthritisTolfenamic AcidMigraineTolfenamic AcidPainTolfenamic AcidDysmenorrhoeaTolfenamic Acid进行性核上性麻痹Tolfenamic AcidOveractive bladderVelufenacinRenal impairmentVelufenacin
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Tolfenamic Acid | Tier C — Watch / trade | - |
| Velufenacin | Tier C — Watch / trade | - |
| AZD-6482 | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-Chlorobenzoic acid→Sodium 2-chlorobenzoate→2-Chlorobenoic acid potassium salt→2-Amino-6-chlorotoluene→2-Bromobenzoic acid→2-Bromobenzoic acid potassium salt
(R)-(1-methylpyrrolidin-3-yl)methyl (3'-chloro-4'-fluoro-[1,1'-biphenyl]-2-yl)carbamate→2-bromobenzoic acid→tert-butyl (R)-3-(hydroxymethyl)pyrrolidine-1-carboxylate→tert-butyl (R)-3-((((2-bromophenyl)carbamoyl)oxy)methyl)pyrrolidine-1-carboxylate→(R)-pyrrolidin-3-ylmethyl (2-bromophenyl)carbamate→(R)-(1-methylpyrrolidin-3-yl)methyl (2-bromophenyl)carbamate→(3-chloro-4-fluorophenyl)boronic acid
propionaldehyde→3-oxobutanamide→3-acetyl-5-methylpyridin-2(1H)-one→1-(2-chloro-5-methylpyridin-3-yl)ethan-1-one→1-(2-amino-5-methylpyridin-3-yl)ethan-1-one→1,3-dimorpholinopropane-1,3-dione→9-acetyl-7-methyl-2-morpholino-4H-pyrido[1,2-a]pyrimidin-4-one→(S)-2-methylpropane-2-sulfinamide→(R)-9-(1-aminoethyl)-7-methyl-2-morpholino-4H-pyrido[1,2-a]pyrimidin-4-one→2-bromobenzoic acid→(R)-2-((1-(7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethyl)amino)benzoic acid
Intermediates available on this site
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