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CAS 886510-09-4
3-fluoro-2-(trifluoromethyl)isonicotinic acid
Codes: JNJ-55308942-001, ITACI-016
Application context (from source-drug indications)
ManiaZanvipixantDiffuse large B-cell lymphomaItacitinibMyeloproliferative neoplasmItacitinibAcute lymphoblastic leukaemiaItacitinibAcute myeloid leukaemiaItacitinibChronic myelomonocytic leukaemiaItacitinib骨髓增生异常-骨髓增生性疾病Itacitinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Zanvipixant | Tier C — Watch / trade | - |
| Itacitinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(S)-(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)(1-(5-fluoropyrimidin-2-yl)-6-methyl-1,4,6,7-tetrahydro-5H-[1,2,3]triazolo[4,5-c]pyridin-5-yl)methanone→3-fluoro-2-(trifluoromethyl)isonicotinic acid→3-fluoro-2-(trifluoromethyl)isonicotinoyl chloride→(S)-2-methylpiperidin-4-one→(S)-1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)-2-methylpiperidin-4-one→2-azido-5-fluoropyrimidine
diphenylmethanamine→2-(chloromethyl)oxirane→1-benzhydrylazetidin-3-ol hydrochloride→tert-butyl 3-hydroxyazetidine-1-carboxylate→tert-butyl 3-oxoazetidine-1-carboxylate→diethyl (cyanomethyl)phosphonate→tert-butyl 3-(cyanomethylene)azetidine-1-carboxylate→4-(4,4,5,5-tetramethyl-1,3-dioxolan-2-yl)-1H-pyrazole→tert-butyl 3-(cyanomethyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)azetidine-1-carboxylate→4-chloro-7H-pyrrolo[2,3-d]pyrimidine→tert-butyl 3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-(cyanomethyl)azetidine-1-carboxylate→2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)azetidin-3-yl)acetonitrile dihydrochloride→1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-one→1,4-dioxa-8-azaspiro[4.5]decane hydrochloride→1,4-dioxa-8-azaspiro[4.5]decane→3-fluoro-2-(trifluoromethyl)isonicotinic acid→(3-fluoro-2-(trifluoromethyl)pyridin-4-yl)(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone→1H-pyrazole→4-iodo-1H-pyrazole→4-iodo-1-(trimethylsilyl)-1H-pyrazole→2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile→2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(1-(3-fluoro-2-(trifluoromethyl)isonicotinoyl)piperidin-4-yl)azetidin-3-yl)acetonitrile adipate
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