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CAS 90-15-3
naphthalen-1-ol
Codes: NAFT-001, NUC-3373-001, CG-200745-006
Application context (from source-drug indications)
排尿困难NaftopidilBenign prostatic hyperplasiaNaftopidil增生NaftopidilColorectal cancerFosifloxuridine nafalbenamideNon-small cell lung cancerFosifloxuridine nafalbenamideMelanomaFosifloxuridine nafalbenamideHodgkin's diseaseFosifloxuridine nafalbenamide间皮组织肿瘤Fosifloxuridine nafalbenamideSquamous cell carcinomaFosifloxuridine nafalbenamidePancreatic cancerivaltinostatMyelodysplastic syndromeivaltinostatSolid tumourivaltinostatFibrosisivaltinostatHaematological malignancyivaltinostat
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Naftopidil | Tier C — Watch / trade | - |
| Fosifloxuridine nafalbenamide | Tier C — Watch / trade | - |
| ivaltinostat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
benzyl ((((2R,3S,5R)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methoxy)(naphthalen-1-yloxy)phosphoryl)-L-alaninate→naphthalen-1-ol→naphthalen-1-yl phosphorodichloridate→benzyl L-alaninate 4-methylbenzenesulfonate→benzyl (chloro(naphthalen-1-yloxy)phosphoryl)-L-alaninate→5-fluoro-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
oxepan-2-one→methyl 6-hydroxyhexanoate→methyl 6-oxohexanoate→1-(tert-butyl) 8-methyl 3-hydroxy-2-methyleneoctanedioate→1-(tert-butyl) 8-methyl (Z)-2-(bromomethyl)oct-2-enedioate→naphthalen-1-ol→1-(tert-butyl) 8-methyl (E)-2-((naphthalen-1-yloxy)methyl)oct-2-enedioate→(E)-8-methoxy-2-((naphthalen-1-yloxy)methyl)-8-oxooct-2-enoic acid→N1,N1-dimethylpropane-1,3-diamine→methyl (E)-8-((3-(dimethylamino)propyl)amino)-7-((naphthalen-1-yloxy)methyl)-8-oxooct-6-enoate→(E)-8-((3-(dimethylamino)propyl)amino)-7-((naphthalen-1-yloxy)methyl)-8-oxooct-6-enoic acid→O-(tetrahydro-2H-pyran-2-yl)hydroxylamine→(E)-N1-(3-(dimethylamino)propyl)-2-((naphthalen-1-yloxy)methyl)-N8-((tetrahydro-2H-pyran-2-yl)oxy)oct-2-enediamide
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