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CAS 98-16-8
3-(trifluoromethyl)aniline
Codes: CINA-016, ALVEL-001
Application context (from source-drug indications)
HypercalcaemiaCinacalcet HydrochlorideSecondary hyperparathyroidismCinacalcet HydrochlorideHyperparathyroidismCinacalcet HydrochloridePrimary hyperparathyroidismCinacalcet HydrochlorideChronic renal impairmentCinacalcet HydrochlorideCardiogenic oedemaCinacalcet HydrochlorideCOVID-19Alvelestatα1抗胰蛋白酶缺乏症AlvelestatEmphysemaAlvelestatChronic obstructive pulmonary diseaseAlvelestat闭塞性细支气管炎AlvelestatGraft-versus-host diseaseAlvelestat
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Cinacalcet Hydrochloride | Tier B — Position early | - |
| Alvelestat | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(R)-1-(naphthalen-1-yl)ethan-1-amine→3-(3-(trifluoromethyl)phenyl)propanoic acid→(R)-N-(1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propanamide→3-(trifluoromethyl)aniline→acrylonitrile→2-chloro-3-(3-(trifluoromethyl)phenyl)propanenitrile→2-chloro-3-(3-(trifluoromethyl)phenyl)propanoic acid
3-(trifluoromethyl)aniline→ethyl 3-chloro-3-oxopropanoate→ethyl 3-oxo-3-[3-(trifluoromethyl)anilino]propanoate →ethyl 3-oxo-3-((3-(trifluoromethyl)phenyl)amino)propanoate→(E)-4-methoxybut-3-en-2-one→6-methyl-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylic acid→1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole→6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylic acid→6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxylic acid→(5-(methylsulfonyl)pyridin-2-yl)methanamine hydrochloride→5-bromopicolinonitrile→5-(methylsulfonyl)picolinonitrile
Intermediates available on this site
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