Garsorasib

Tier C — Watch / trade

Garsorasib

Originator

2024

First approval

Expiry (public)

No sales data

Peak sales

Small molecule

Type

Targets：KRAS G12C

Indications (approved)：Non-small cell lung cancer

Regional status

Phase II

2020-10-02

China

Approved

2024-11-05

Japan

Synthetic routes & intermediates3 routes

Originator routes × 0Optimised (non-patent) × 3Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OptimisedRoute 1Steps 5 · Total yield /

(I)1114845-1-a82671-06-5(II)1114845-1-a113237-20-0(III)1114845-1-a79-37-8(IV)1114845-1-a2387291-26-9(V)1114845-1-a5413-85-4(VI)1114845-1-a411235-57-9(VII)1114845-1-a—(VIII)1114845-1-a—(IX)1114845-1-a2388477-89-0(X)1114845-1-a—(XI)1114845-1-a1418130-40-1(XII)1114845-1-a548762-66-9(XIII)1114845-1-a814-68-6(XIV)1114845-1-a—API · Garsorasib

Code	CAS No.	Intermediate
(I)1114845-1-a	82671-06-5	2,6-Bis(chloranyl)-5-fluoranylpyridine-3-carboxylic acid
(II)1114845-1-a	113237-20-0 Available	2,6-Dichloro-5-fluoronicotinamide
(III)1114845-1-a	79-37-8	2-Chloro-2-oxoacetyl chloride
(IV)1114845-1-a	2387291-26-9	4,6-Dicyclopropylpyrimidin-5-amine
(V)1114845-1-a	5413-85-4	4,6-Dichloropyrimidin-5-amine
(VI)1114845-1-a	411235-57-9 Available	(Cyclopropyl)boronic acid
(VII)1114845-1-a	-	2,6-Dichloro-N-[(4,6-dicyclopropylpyrimidin-5-yl)carbamoyl]-5-fluoropyridine-3-carboxamide
(VIII)1114845-1-a	-	7-Chloro-1-(4,6-dicyclopropylpyrimidin-5-yl)-6-fluoropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
(IX)1114845-1-a	2388477-89-0	Trifluoroacetic acid 1-[(2R,5S)-2,5-dimethylpiperazin-1-yl]prop-2-en-1-one
(X)1114845-1-a	-	7-Chloro-1-(4,6-dicyclopropylpyrimidin-5-yl)-4-[(2S,5R)-2,5-dimethyl-4-(prop-2-enoyl)piperazin-1-yl]-6-fluoropyrido[2,3-d]pyrimidin-2(1H)-one
(XI)1114845-1-a	1418130-40-1	2-Fluoro-6-aminophenylboronic acid pinacol ester
(XII)1114845-1-a	548762-66-9	tert-Butyl (2S,5R)-2,5-dimethylpiperazine-1-carboxylate
(XIII)1114845-1-a	814-68-6 Available	2-Propenoyl chloride
(XIV)1114845-1-a	-	tert-Butyl (2S,5R)-2,5-dimethyl-4-(prop-2-enoyl)piperazine-1-carboxylate

OptimisedRoute 2Steps 5 · Total yield /

(I)1114845-2-a—(II)1114845-2-a309915-46-6(III)1114845-2-a—(IV)1114845-2-a1418130-40-1(V)1114845-2-a—(VI)1114845-2-a—(VII)1114845-2-a625-36-5(VIII)1114845-2-a2650523-66-1API · Garsorasib

Code	CAS No.	Intermediate
(I)1114845-2-a	-	7-Chloro-1-(4,6-dicyclopropylpyrimidin-5-yl)-6-fluoropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
(II)1114845-2-a	309915-46-6	(2R,5S)-1-Boc-2,5-dimethylpiperazine
(III)1114845-2-a	-	tert-Butyl (2R,5S)-4-[7-chloro-1-(4,6-dicyclopropylpyrimidin-5-yl)-6-fluoro-2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-4-yl]-2,5-dimethylpiperazine-1-carboxylate
(IV)1114845-2-a	1418130-40-1	2-Fluoro-6-aminophenylboronic acid pinacol ester
(V)1114845-2-a	-	tert-Butyl (2R,5S)-4-[7-(2-amino-6-fluorophenyl)-1-(4,6-dicyclopropylpyrimidin-5-yl)-6-fluoro-2-oxo-1,2-dihydropyrido[2,3-d]pyrimidin-4-yl]-2,5-dimethylpiperazine-1-carboxylate
(VI)1114845-2-a	-	7-(2-Amino-6-fluorophenyl)-1-(4,6-dicyclopropylpyrimidin-5-yl)-4-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-6-fluoropyrido[2,3-d]pyrimidin-2(1H)-one
(VII)1114845-2-a	625-36-5 Available	(Chloromethyl)acetyl chloride
(VIII)1114845-2-a	2650523-66-1	7-(2-Amino-6-fluorophenyl)-4-[(2S,5R)-4-(3-chloropropanoyl)-2,5-dimethylpiperazin-1-yl]-1-(4,6-dicyclopropylpyrimidin-5-yl)-6-fluoropyrido[2,3-d]pyrimidin-2(1H)-one

OptimisedRoute 3Steps 2 · Total yield /

(I)1114845-3-a38496-18-3(II)1114845-3-a38025-90-0(III)1114845-3-a58584-93-3(IV)1114845-3-a80289-91-4(V)1114845-3-a54718-39-7API · Garsorasib

Code	CAS No.	Intermediate
(I)1114845-3-a	38496-18-3	2,6-Dichloronicotinic acid
(II)1114845-3-a	38025-90-0	2-Chloro-6-hydroxynicotinic acid
(III)1114845-3-a	58584-93-3	2,5-Dichloro-6-hydroxynicotinic acid
(IV)1114845-3-a	80289-91-4	2,3,6-Trichloro-5-(trifluoromethyl)pyridine
(V)1114845-3-a	54718-39-7	2,5,6-Trichloronicotinic acid

Frequently asked questions

What are the approved indications of Garsorasib?

Approved indications include: Non-small cell lung cancer.

When does the Garsorasib patent expire?

No public expiry year is available for Garsorasib yet; this page updates once verified.

How many synthesis routes are recorded for Garsorasib?

3 synthesis routes are recorded; the shortest is 2 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Garsorasib intermediates?

4 intermediate CAS of Garsorasib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Garsorasib intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-10-22