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CAS 814-68-6
acryloyl chloride2-Propenoyl chlorideAcryloyl chloride2-Propenoyl chloride; Acrylic acid chloride; Acrylic chloride; Acryloyl chloride
Codes: OSIM-010, IBRT-008, (IX)461018-2-a, (IV)461018-6-a, (IX)461018-8-a, (XI)461018-10-a, (X)461018-11-a, (VII)461018-17-a, (X)461018-20-a, (IV)461018-21-a, (XI)461018-25-a, (XII)461018-28-a +12 more
Application context (from source-drug indications)
Non-small cell lung cancerOsimertinib MesylateWaldenström macroglobulinaemiaIbrutinibChronic lymphocytic leukaemiaIbrutinibMantle cell lymphomaIbrutinibGraft-versus-host diseaseIbrutinibNon-small cell lung cancerOlmutinibHIV infectionDarunavir Ethanolate/RitonavirHIV infectionDarunavir Ethanolate/CobicistatHIV infectionDarunavir EthanolateNon-small cell lung cancerFulzerasibColorectal cancerFulzerasibSolid tumourFulzerasibNon-small cell lung cancerLazertinib MesylateHepatic function declineLazertinib MesylateMarginal zone B-cell lymphomaOrelabrutinibMantle cell lymphomaOrelabrutinibChronic lymphocytic leukaemiaOrelabrutinibImmune thrombocytopenic purpuraOrelabrutinibSystemic lupus erythematosusOrelabrutinibMultiple sclerosisOrelabrutinibNon-small cell lung cancerZongertinibLung cancerZongertinib食道腺癌Zongertinib食管胃结合部肿瘤ZongertinibGastric cancerZongertinibMetastatic breast cancerZongertinibNon-small cell lung cancerGarsorasibColorectal cancerGarsorasibSolid tumourGarsorasibRenal cell carcinomaGarsorasibPancreatic cancerGarsorasibNon-small cell lung cancerSunvozertinibB-cell lymphomaSunvozertinibNon-Hodgkin lymphomaSunvozertinibNon-small cell lung cancerAbivertinibNon-Hodgkin lymphomaAbivertinibLymphomaAbivertinibChronic lymphocytic leukaemiaAbivertinibDiffuse large B-cell lymphomaAbivertinibMantle cell lymphomaAbivertinib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Osimertinib Mesylate | Tier A — Act now | 2031 |
| Ibrutinib | Tier A — Act now | 2027 |
| Olmutinib | Tier C — Watch / trade | - |
| Darunavir Ethanolate/Ritonavir | Tier C — Watch / trade | - |
| Darunavir Ethanolate/Cobicistat | Tier C — Watch / trade | - |
| Darunavir Ethanolate | Tier B — Position early | - |
| Fulzerasib | Tier C — Watch / trade | - |
| Lazertinib Mesylate | Tier C — Watch / trade | - |
| Orelabrutinib | Tier C — Watch / trade | - |
| Zongertinib | Tier C — Watch / trade | - |
| Garsorasib | Tier C — Watch / trade | - |
| Sunvozertinib | Tier C — Watch / trade | - |
| Abivertinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1H-indole→2,4-dichloropyrimidine→3-(2-chloropyrimidin-4-yl)-1H-indole→3-(2-chloropyrimidin-4-yl)-1-methyl-1H-indole→4-fluoro-2-methoxy-5-nitroaniline→N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine→N1,N1,N2-trimethylethane-1,2-diamine→N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)-2-nitrobenzene-1,4-diamine→N1-(2-(dimethylamino)ethyl)-5-methoxy-N1-methyl-N4-(4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)benzene-1,2,4-triamine→acryloyl chloride→methanesulfonic acid
3-(2-chloropyrimidin-4-yl)-1-methyl-1H-indole→4-fluoro-2-methoxy-5-nitroaniline→N1,N1,N2-trimethylethane-1,2-diamine→acryloyl chloride→tert-butyl (4-fluoro-2-methoxy-5-nitrophenyl)carbamate→tert-butyl (4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxy-5-nitrophenyl)carbamate→tert-butyl (5-amino-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenyl)carbamate→N-(5-amino-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
N1,N1,N2-trimethylethane-1,2-diamine→acryloyl chloride→N-(5-amino-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide→2-fluoro-4-iodoaniline→hexane-2,5-dione→1-(2-fluoro-4-iodophenyl)-2,5-dimethyl-1H-pyrrole→1-(2-fluoro-4-methoxyphenyl)-2,5-dimethyl-1H-pyrrole→2-fluoro-4-methoxyaniline→N-(2-fluoro-4-methoxyphenyl)acrylamide→N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide→N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-nitrophenyl)acrylamide→N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-5-guanidino-4-methoxyphenyl)acrylamide→(E)-3-(dimethylamino)-1-(1-methyl-1H-indol-3-yl)prop-2-en-1-one→1-(1-methyl-1H-indol-3-yl)ethanone
4-phenoxybenzoic acid→2-(hydroxy(4-phenoxyphenyl)methylene)malononitrile→2-(methoxy(4-phenoxyphenyl)methylene)malononitrile→5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile→3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→(S)-tert-butyl 3-hydroxypiperidine-1-carboxylate→(R)-tert-butyl 3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate→acryloyl chloride→1H-pyrazolo[3,4-d]pyrimidin-4-amine→3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine→tert-butyl 4-(((6-amino-5-chloropyrimidin-4-yl)amino)methyl)piperidine-1-carboxylate
3-Bromo-1H-pyrazolo[3,4-d]pyrimidin-4-amine→(4-Phenoxyphenyl)boranediol→3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine→N-Boc-3(S)-Hydroxypiperidine→2-Propenoyl chloride→(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester→Perfluoroacetyl chloride→tert-Butyl (3R)-3-[3-(4-phenoxyphenyl)-4-[(trifluoroacetyl)amino]-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate→2,2,2-Trifluoro-N-[3-(4-phenoxyphenyl)-1-[(3R)-piperidin-3-yl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]acetamide→N-[1-[(3R)-1-Acryloylpiperidin-3-yl]-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]-2,2,2-trifluoroacetamide
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 3-phenyl-1H-pyrazole-4-carbaldehyde Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 4-Chloro-2-(methylsulfonyl)pyrimidine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 4-chloro-N-(2-methoxy-4-morpholino-5-nitrophenyl)pyrimidin-2-amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 1-(2-((2-methoxy-4-morpholino-5-nitrophenyl)amino)pyrimidin-4-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)-N-(2-methoxy-4-morpholino-5-nitrophenyl)pyrimidin-2-amine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | N1-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidin-2-yl)-6-methoxy-4-morpholinobenzene-1,3-diamine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 4-fluoro-2-Methoxy-5-nitroaniline Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | 3-(2-chloropyriMidin-4-yl)-1-Methylindole Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 1,4-BenzenediaMine, N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]-2-nitro- Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | N1-[2-(diMethylaMino)ethyl]-5-Methoxy-N1-Methyl-N4-[4-(1-Methyl-1H-indol-3-yl)-2-pyriMidinyl]benzene-1,2,4-triamine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | N,N,N'-Trimethylethylenediamine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Nantong cGMP Site | 4-Methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile Pharmaceutical Intermediates | On request | On request | On request | — | |
| Unibest Taizhou GMP-like Site | N-(3-Chloropropyl)morpholine Pharmaceutical Intermediates | On request | On request | On request | — | |
| Qualified Partner — East China API Works | 5-hydroxy-4-methoxy-2-nitrobenzoic acid ethyl ester Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.