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Nerandomilast
Tier C — Watch / tradeNerandomilast
Boehringer Ingelheim
Originator
2025
First approval
-
Expiry (public)
No sales data
Peak sales
Small molecule
Type
Targets：PDE4B
Brand：Jascayd
Indications (approved)：Idiopathic pulmonary fibrosis, Interstitial lung disease, Pulmonary fibrosis
Regional status
US
Approved
2025-10-07
EU
Approved
2026-07-15
China
Approved
2025-10-21
Japan
Approved
2026-05-18
Synthetic routes & intermediates3 routes
Originator routes × 0Optimised (non-patent) × 3Process routes × 0
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
OptimisedRoute 1Steps 8 · Total yield /
(I)805433-1-a2365-48-2(II)805433-1-a96-33-3(III)805433-1-a7400-45-5(IV)805433-1-a—(V)805433-1-a57-13-6(VI)805433-1-a1196101-46-8(VII)805433-1-a913581-92-7(VIII)805433-1-a74901-69-2(IXa)805433-1-a—(IXb)805433-1-a,(IXb)805433-1-c1392213-15-8(X)805433-1-a98071-16-0(XI)805433-1-a—(XII)805433-1-a1423719-36-1(XIIIa)805433-1-a,(XIIIa)805433-1-b—(XIIIb)805433-1-a,(XIIIb)805433-1-b1423719-37-2(XIIIc)805433-1-a,(XIIIc)805433-1-b1423719-41-8(XIV)805433-1-a,(XIV)805433-1-b—(XVIIa)805433-1-b951625-94-8API · Nerandomilast
| Code | CAS No. | Intermediate |
|---|---|---|
| (I)805433-1-a | 2365-48-2 | 2-Mercaptoacetic acid methyl ester |
| (II)805433-1-a | 96-33-3 | 2-Propenoic acid methyl ester |
| (III)805433-1-a | 7400-45-5 | 3-(Methoxycarbonylmethylthio)propionsauremethylester |
| (IV)805433-1-a | - | 2-Carbomethoxy-2,3,4,5-tetrahydrothiophen-3-one |
| (V)805433-1-a | 57-13-6 | Carbamide |
| (VI)805433-1-a | 1196101-46-8 | 3-Ureido-4,5-dihydro-thiophene-2-carboxylic acid methyl ester |
| (VII)805433-1-a | 913581-92-7 | 6,7-Dihydrothieno[3,2-d]pyrimidine-2,4-diol |
| (VIII)805433-1-a | 74901-69-2Available | 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine |
| (IXa)805433-1-a | - | (1-Aminocyclobutyl)methanol tosylate |
| (IXb)805433-1-a,(IXb)805433-1-c | 1392213-15-8Available | (1-Aminocyclobutyl)methanol hydrogen chloride |
| (X)805433-1-a | 98071-16-0 | 1-Aminocyclobutanecarboxylic acid hydrochloride |
| (XI)805433-1-a | - | [1-[(2-Chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl)amino]cyclobutyl]methanol |
| (XII)805433-1-a | 1423719-36-1 | (5R)-2-Chloro-4-[[1-(hydroxymethyl)cyclobutyl]amino]-6,7-dihydro-5H-5lambda4-thieno[3,2-d]pyrimidin-5-one |
| (XIIIa)805433-1-a,(XIIIa)805433-1-b | - | 5-Chloro-2-(piperidin-4-yl)pyrimidine hydrogen chloride |
| (XIIIb)805433-1-a,(XIIIb)805433-1-b | 1423719-37-2 | 4-Methylbenzene-1-sulfonic acid 5-chloro-2-(piperidin-4-yl)pyrimidine |
| (XIIIc)805433-1-a,(XIIIc)805433-1-b | 1423719-41-8 | 5-Chloro-2-(piperidin-4-yl)pyrimidine sulfate |
| (XIV)805433-1-a,(XIV)805433-1-b | - | 4-(5-Chloropyrimidin-2-yl)piperidin-1-ium hexafluoridophosphate(1-) |
| (XVIIa)805433-1-b | 951625-94-8 | Piperidine-4-carboximidamide |
OptimisedRoute 2Steps 4 · Total yield /
(XIIIa)805433-1-a,(XIIIa)805433-1-b—(XIIIb)805433-1-a,(XIIIb)805433-1-b1423719-37-2(XIIIc)805433-1-a,(XIIIc)805433-1-b1423719-41-8(XIV)805433-1-a,(XIV)805433-1-b—(XIX)805433-1-b5750-76-5(XV)805433-1-b4395-98-6(XVI)805433-1-b—(XVIIa)805433-1-b951625-94-8(XVIIb)805433-1-b1245647-87-3(XVIII)805433-1-b249561-98-6(XX)805433-1-b22536-67-0(XXI)805433-1-b874676-81-0(XXII)805433-1-b286961-14-6(XXIII)805433-1-b—(XXIV)805433-1-b—API · Nerandomilast
| Code | CAS No. | Intermediate |
|---|---|---|
| (XIIIa)805433-1-a,(XIIIa)805433-1-b | - | 5-Chloro-2-(piperidin-4-yl)pyrimidine hydrogen chloride |
| (XIIIb)805433-1-a,(XIIIb)805433-1-b | 1423719-37-2 | 4-Methylbenzene-1-sulfonic acid 5-chloro-2-(piperidin-4-yl)pyrimidine |
| (XIIIc)805433-1-a,(XIIIc)805433-1-b | 1423719-41-8 | 5-Chloro-2-(piperidin-4-yl)pyrimidine sulfate |
| (XIV)805433-1-a,(XIV)805433-1-b | - | 4-(5-Chloropyrimidin-2-yl)piperidin-1-ium hexafluoridophosphate(1-) |
| (XIX)805433-1-b | 5750-76-5 | 2,4,5-Trichloropyrimidine |
| (XV)805433-1-b | 4395-98-6 | 4-Piperidinecarbonitrile |
| (XVI)805433-1-b | - | Methyl piperidine-4-carboximidate hydrogen chloride |
| (XVIIa)805433-1-b | 951625-94-8 | Piperidine-4-carboximidamide |
| (XVIIb)805433-1-b | 1245647-87-3 | Piperidine-4-carboximidamide hydrogen chloride |
| (XVIII)805433-1-b | 249561-98-6 | 2-Chloro-1,3-bis(dimentylamino)trimethinium hexafluorophosphate |
| (XX)805433-1-b | 22536-67-0 | 2,5-Dichloropyrimidine |
| (XXI)805433-1-b | 874676-81-0 | 5-Chloro-2-iodopyrimidine |
| (XXII)805433-1-b | 286961-14-6 | (1-tert-Butoxycarbonyl-1,2,3,6-tetrahydropyridin-4-yl)boronic acid pinacol ester |
| (XXIII)805433-1-b | - | Boc-4-(5-chloropyrimidin-2-yl)-3,6-dihydropyridine |
| (XXIV)805433-1-b | - | Boc-4-(5-chloropyrimidin-2-yl)piperidine |
OptimisedRoute 3Steps 3 · Total yield /
(IXb)805433-1-a,(IXb)805433-1-c1392213-15-8(XIIIc)805433-1-a,(XIIIc)805433-1-b1423719-41-8(XXV)805433-1-c120728-10-1(XXVI)805433-1-c—(XXVII)805433-1-c1142211-17-3API · Nerandomilast
| Code | CAS No. | Intermediate |
|---|---|---|
| (IXb)805433-1-a,(IXb)805433-1-c | 1392213-15-8Available | (1-Aminocyclobutyl)methanol hydrogen chloride |
| (XIIIc)805433-1-a,(XIIIc)805433-1-b | 1423719-41-8 | 5-Chloro-2-(piperidin-4-yl)pyrimidine sulfate |
| (XXV)805433-1-c | 120728-10-1Available | 1-((1,1-Dimethylethoxycarbonyl)amino)cyclobutanecarboxylic acid |
| (XXVI)805433-1-c | - | Methyl 1-(Boc-amino)cyclobutanecarboxylate |
| (XXVII)805433-1-c | 1142211-17-3 | 1-(Boc-amino)-1-(hydroxymethyl)cyclobutane |
Frequently asked questions
What are the approved indications of Nerandomilast?
Approved indications include: Idiopathic pulmonary fibrosis, Interstitial lung disease, Pulmonary fibrosis.
When does the Nerandomilast patent expire?
No public expiry year is available for Nerandomilast yet; this page updates once verified.
How many synthesis routes are recorded for Nerandomilast?
3 synthesis routes are recorded; the shortest is 3 steps with / total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Nerandomilast intermediates?
3 intermediate CAS of Nerandomilast are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Nerandomilast intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-10-22