methyl acrylate (96-33-3) intermediate

Application context (from source-drug indications)

Multiple myelomaPanobinostat LactateGliomaPanobinostat LactateDiffuse intrinsic pontine gliomaPanobinostat LactateDiffuse midline gliomaPanobinostat LactateMyelodysplastic syndromePanobinostat LactateAcute myeloid leukaemiaPanobinostat LactateOsteoporosisIbandronate Sodium Hydrate/ColecalciferolOsteoporosisIbandronate Sodium HydratePostmenopausal osteoporosisIbandronate Sodium HydrateHypercalcaemiaIbandronate Sodium HydrateBone injuryIbandronate Sodium HydrateBreast cancerIbandronate Sodium HydrateMetastatic cancerIbandronate Sodium HydrateIdiopathic pulmonary fibrosisNerandomilastInterstitial lung diseaseNerandomilastPulmonary fibrosisNerandomilast肌炎NerandomilastSystemic sclerosisNerandomilast肌病Nerandomilast

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Panobinostat Lactate	Tier C — Watch / trade	-
Ibandronate Sodium Hydrate/Colecalciferol	Tier C — Watch / trade	-
Ibandronate Sodium Hydrate	Tier C — Watch / trade	-
Nerandomilast	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Panobinostat LactateOptimised routesteps: 5total yield: /

2-(2-methyl-1H-indol-3-yl)ethan-1-amine→methyl (E)-3-(4-formylphenyl)acrylate→4-bromobenzaldehyde→methyl acrylate→methyl (E)-3-(4-(((2-(2-methyl-1H-indol-3-yl)ethyl)amino)methyl)phenyl)acrylate hydrochloride→2-hydroxypropanoic acid→phenylhydrazine→5-chloropentan-2-one

Ibandronate Sodium Hydrate/ColecalciferolOriginator routesteps: 7total yield: /

pentan-1-amine→benzaldehyde→3-(methyl(pentyl)amino)propanoic acid hydrochloride→(E)-N-benzylidenepentan-1-amine→N-benzyl-N-methylpentan-1-amine→N-methylpentan-1-amine→methyl acrylate→ methyl 3-[methyl(pentyl)amino]propanoate →3-(methyl(pentyl)amino)propanoic acid

Ibandronate Sodium Hydrate/ColecalciferolOptimised routesteps: 4total yield: 315.60 g

3-(methyl(pentyl)amino)propanoic acid hydrochloride→N-methylpentan-1-amine→methyl acrylate→ methyl 3-[methyl(pentyl)amino]propanoate →3-[methyl(pentyl)amino]propanoic acid;hydrochloride →diethyl carbonate

Ibandronate Sodium HydrateOriginator routesteps: 7total yield: /

pentan-1-amine→benzaldehyde→3-(methyl(pentyl)amino)propanoic acid hydrochloride→(E)-N-benzylidenepentan-1-amine→N-benzyl-N-methylpentan-1-amine→N-methylpentan-1-amine→methyl acrylate→ methyl 3-[methyl(pentyl)amino]propanoate →3-(methyl(pentyl)amino)propanoic acid

Ibandronate Sodium HydrateOptimised routesteps: 4total yield: 315.60 g

3-(methyl(pentyl)amino)propanoic acid hydrochloride→N-methylpentan-1-amine→methyl acrylate→ methyl 3-[methyl(pentyl)amino]propanoate →3-[methyl(pentyl)amino]propanoic acid;hydrochloride →diethyl carbonate

Intermediates available on this site

No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.