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CAS 1191-99-7
2,3-dihydrofuran
Codes: DARU-001, CEBR-008
Application context (from source-drug indications)
HIV infectionDarunavir Ethanolate/RitonavirHIV infectionDarunavir Ethanolate/CobicistatHIV infectionDarunavir EthanolatePainCebranopadol hemicitrate急性疼痛Cebranopadol hemicitrate神经痛Cebranopadol hemicitrateLow back painCebranopadol hemicitrateSubstance-related disorderCebranopadol hemicitrateChronic painCebranopadol hemicitrate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Darunavir Ethanolate/Ritonavir | Tier C — Watch / trade | - |
| Darunavir Ethanolate/Cobicistat | Tier C — Watch / trade | - |
| Darunavir Ethanolate | Tier B — Position early | - |
| Cebranopadol hemicitrate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2,3-dihydrofuran→prop-2-yn-1-ol→(2R,3S)-3-iodo-2-(prop-2-yn-1-yloxy)tetrahydrofuran→(3aS,6aR)-3-methylenehexahydrofuro[2,3-b]furan→(3aR,6aR)-tetrahydrofuro[2,3-b]furan-3(2H)-one→(3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol→(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol→bis(2,5-dioxopyrrolidin-1-yl) carbonate→2,5-dioxopyrrolidin-1-yl ((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl) carbonate→4-amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide→2-vinyloxirane→(E)-4-phenylbut-2-en-1-ol→((2R,3R)-3-benzyloxiran-2-yl)methanol→(2S,3S)-3-azido-4-phenylbutane-1,2-diol→(S)-2-((S)-1-azido-2-phenylethyl)oxirane→2-methylpropan-1-amine→(2R,3S)-3-azido-1-(isobutylamino)-4-phenylbutan-2-ol→4-nitrobenzenesulfonyl chloride
2,3-dihydrofuran→prop-2-yn-1-ol→(2R,3S)-3-iodo-2-(prop-2-yn-1-yloxy)tetrahydrofuran→(3aS,6aR)-3-methylenehexahydrofuro[2,3-b]furan→(3aR,6aR)-tetrahydrofuro[2,3-b]furan-3(2H)-one→(3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol→(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol→bis(2,5-dioxopyrrolidin-1-yl) carbonate→2,5-dioxopyrrolidin-1-yl ((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl) carbonate→4-amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide→2-vinyloxirane→(E)-4-phenylbut-2-en-1-ol→((2R,3R)-3-benzyloxiran-2-yl)methanol→(2S,3S)-3-azido-4-phenylbutane-1,2-diol→(S)-2-((S)-1-azido-2-phenylethyl)oxirane→2-methylpropan-1-amine→(2R,3S)-3-azido-1-(isobutylamino)-4-phenylbutan-2-ol→4-nitrobenzenesulfonyl chloride
2,3-dihydrofuran→prop-2-yn-1-ol→(2R,3S)-3-iodo-2-(prop-2-yn-1-yloxy)tetrahydrofuran→(3aS,6aR)-3-methylenehexahydrofuro[2,3-b]furan→(3aR,6aR)-tetrahydrofuro[2,3-b]furan-3(2H)-one→(3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol→(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol→bis(2,5-dioxopyrrolidin-1-yl) carbonate→2,5-dioxopyrrolidin-1-yl ((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl) carbonate→4-amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide→2-vinyloxirane→(E)-4-phenylbut-2-en-1-ol→((2R,3R)-3-benzyloxiran-2-yl)methanol→(2S,3S)-3-azido-4-phenylbutane-1,2-diol→(S)-2-((S)-1-azido-2-phenylethyl)oxirane→2-methylpropan-1-amine→(2R,3S)-3-azido-1-(isobutylamino)-4-phenylbutan-2-ol→4-nitrobenzenesulfonyl chloride
1,4-dioxaspiro[4.5]decan-8-one→N-methyl-1,4-dioxaspiro[4.5]decan-8-imine→4-(methylamino)-4-phenylcyclohexan-1-one→4-(dimethylamino)-4-phenylcyclohexan-1-one→2-(5-fluoro-1H-indol-3-yl)ethan-1-ol→(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine→(4-fluorophenyl)hydrazine hydrochloride→2,3-dihydrofuran
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