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CAS 4746-97-8
1,4 Cyclohexanedione ethylene ketal1,4-dioxaspiro[4.5]decan-8-one1,4-Dioxaspiro[4.5]decan-8-one
Codes: (I)1024528-1-a,(I)1024528-1-d, (XI)1024528-3-b, CEBR-001, DEXP-001
Application context (from source-drug indications)
Non-small cell lung cancerPralsetinibThyroid cancerPralsetinibMedullary thyroid cancerPralsetinibPainCebranopadol hemicitrate急性疼痛Cebranopadol hemicitrate神经痛Cebranopadol hemicitrateLow back painCebranopadol hemicitrateSubstance-related disorderCebranopadol hemicitrateChronic painCebranopadol hemicitrate肺嗜酸粒细胞增多Dexpramipexole DihydrochlorideAsthmaDexpramipexole DihydrochlorideChronic obstructive pulmonary diseaseDexpramipexole Dihydrochloride高嗜酸性粒细胞综合征Dexpramipexole DihydrochlorideAmyotrophic lateral sclerosisDexpramipexole Dihydrochloride嗜酸粒细胞性哮喘Dexpramipexole Dihydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Pralsetinib | Tier C — Watch / trade | 2031 |
| Cebranopadol hemicitrate | Tier C — Watch / trade | - |
| Dexpramipexole Dihydrochloride | Tier C — Watch / trade | - |
| Eptazocine hydrobromide | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1,4 Cyclohexanedione ethylene ketal→Methyl 8-methoxy-1,4-dioxaspiro[4.5]decane-8-carboxylate→Methyl 1-methoxy-4-oxocyclohexane-1-carboxylate→Methyl 4-hydroxy-1-methoxycyclohexane-1-carboxylate→Methyl 4-iodo-1-methoxycyclohexane-1-carboxylate→2-Chloro-4-methyl-6-(methylsulfanyl)pyrimidine→2,4-Dichloro-6-methylpyrimidine→Methyl 1-methoxy-4-[4-methyl-6-(methylsulfanyl)pyrimidin-2-yl]cyclohexane-1-carboxylate→Methyl 4-[4-(methanesulfonyl)-6-methylpyrimidin-2-yl]-1-methoxycyclohexane-1-carboxylate→Methyl 1-methoxy-4-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)cyclohexane-1-carboxylate→Methyl 4-(4-chloro-6-methylpyrimidin-2-yl)-1-methoxycyclohexane-1-carboxylate
1,4 Cyclohexanedione ethylene ketal→Methyl 1-methoxy-4-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)cyclohexane-1-carboxylate→1,4-Dioxaspiro[4.5]decane-8-carbonitrile→N-Hydroxy-1,4-dioxaspiro[4.5]decane-8-carboximidamide→1,4-Dioxaspiro[4.5]decane-8-carboximidamide→1-Ethoxybutane-1,3-dione→2-(1,4-Dioxaspiro[4.5]decan-8-yl)-6-methylpyrimidin-4-ol→4-(4-Hydroxy-6-methylpyrimidin-2-yl)cyclohexan-1-one
Methyl 4-cyano-1-methoxycyclohexane-1-carboxylate→(1S)-1-[6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl]ethan-1-amine hydrogen chloride→1,4 Cyclohexanedione ethylene ketal→Methyl 8-methoxy-1,4-dioxaspiro[4.5]decane-8-carboxylate→Methyl 1-methoxy-4-oxocyclohexane-1-carboxylate→1,4-Dioxaspiro[4.5]decane-8-carbonitrile→4-Oxocyclohexane-1-carbonitrile
1,4-dioxaspiro[4.5]decan-8-one→N-methyl-1,4-dioxaspiro[4.5]decan-8-imine→4-(methylamino)-4-phenylcyclohexan-1-one→4-(dimethylamino)-4-phenylcyclohexan-1-one→2-(5-fluoro-1H-indol-3-yl)ethan-1-ol→(1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4-b]indol]-4-amine→(4-fluorophenyl)hydrazine hydrochloride→2,3-dihydrofuran
1,4-dioxaspiro[4.5]decan-8-one→(1,4-dioxaspiro[4.5]dec-7-en-8-yloxy)trimethylsilane→5,7-dihydro-4H-spiro[benzo[d]thiazole-6,2'-[1,3]dioxolan]-2-amine→2-amino-4,5-dihydrobenzo[d]thiazol-6(7H)-one→N-(6-oxo-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide→(R)-N-(6-hydroxy-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide→(S)-2-acetamido-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl benzoate→(S)-N-(6-hydroxy-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide→(S)-2-acetamido-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl 4-methylbenzenesulfonate→(R)-N-(6-azido-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide→(R)-N-(6-amino-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide→(R)-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine→propyl 4-methylbenzenesulfonate
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