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CAS 16153-81-4
4-(4-methylpiperazin-1-yl)aniline
Codes: OLMU-007, PHA-848125-014
Application context (from source-drug indications)
Non-small cell lung cancerOlmutinibNon-small cell lung cancerMilciclib maleate胸腺瘤Milciclib maleateHepatocellular carcinomaMilciclib maleateSolid tumourMilciclib maleate
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Olmutinib | Tier C — Watch / trade | - |
| Milciclib maleate | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Methyl 3-aminothiophene-2-carboxylate→Urea→Thieno[3,2-d]pyrimidine-2,4(1H,3H)-dione→2,4-dichlorothieno[3,2-d]pyrimidine→3-nitrophenol→2-chloro-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidine→4-(4-methylpiperazin-1-yl)aniline→N-(4-(4-methylpiperazin-1-yl)phenyl)-4-(3-nitrophenoxy)thieno[3,2-d]pyrimidin-2-amine→4-(3-aminophenoxy)-N-(4-(4-methylpiperazin-1-yl)phenyl)thieno[3,2-d]pyrimidin-2-amine→Acryloyl chloride
2,4-dichlorothieno[3,2-d]pyrimidine→4-(4-methylpiperazin-1-yl)aniline→N-(3-hydroxyphenyl)acrylamide→N-(3-((2-chlorothieno[3,2-d]pyrimidin-4-yl)oxy)phenyl)acrylamide
(Z)-ethyl 6-((dimethylamino)methylene)-1,4,4-trimethyl-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate→guanidine hydrochloride→ethyl 8-amino-1,4,4-trimethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate→isopentyl nitrite→ethyl 8-iodo-1,4,4-trimethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylate→8-iodo-1,4,4-trimethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid→5,5-dimethylcyclohexane-1,3-dione→3-methoxy-5,5-dimethylcyclohex-2-enone→4,4-dimethyl-7-oxabicyclo[4.1.0]heptan-2-one→2-methoxy-5,5-dimethylcyclohex-2-enone→ethyl 1,4,4-trimethyl-7-oxo-4,5,6,7-tetrahydro-1H-indazole-3-carboxylate→1,1-di-tert-butoxy-N,N-dimethylmethanamine→8-iodo-N,1,4,4-tetramethyl-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide→4-(4-methylpiperazin-1-yl)aniline
Intermediates available on this site
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