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CAS 289686-69-7
2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoyl chloride2-[3,5-Bis(trifluoromethyl)phenyl]-2-methylpropanoyl chloride
Codes: Elinzanetant-012, (IX)448314-1-a, (XIX)448314-2-b, FOSNE-011, NETUP-010
Application context (from source-drug indications)
Hot flushesElinzanetantVasomotor symptomsElinzanetantHR阳性乳腺癌Elinzanetant睡眠障碍ElinzanetantMenopausal symptomsElinzanetantOpioid dependenceElinzanetantChemotherapy-induced nausea and vomitingFosnetupitantChemotherapy-induced nausea and vomitingNetupitantNeoplasmNetupitant
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Elinzanetant | Tier C — Watch / trade | - |
| Fosnetupitant | Tier C — Watch / trade | - |
| Netupitant | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
4-(tert-butoxycarbonyl)morpholine-3-carboxylic acid→tert-butyl 3-(((R)-3-hydroxy-1-methoxy-1-oxopropan-2-yl)carbamoyl)morpholine-4-carboxylate→(7R)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazine-6,9-dione→((7S)-octahydropyrazino[2,1-c][1,4]oxazin-7-yl)methanol→(7S,9aS)-7-(((tert-butyldimethylsilyl)oxy)methyl)octahydropyrazino[2,1-c][1,4]oxazine→2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide→2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-((7S,9aS)-7-(((tert-butyldimethylsilyl)oxy)methyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl)-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide→tert-butyl (6-chloro-4-methylpyridin-3-yl)(methyl)carbamate→6-chloro-N,4-dimethylpyridin-3-amine→(4-fluoro-2-methylphenyl)boronic acid→6-chloro-4-(4-fluoro-2-methylphenyl)-N-methylpyridin-3-amine→2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoyl chloride
3-Amino-6-chloropyridine→1,1-Dimethylethyl (6-Chloro-3-pyridinyl)carbamate→N-(6-Chloro-4-iodopyridin-3-yl)carbamic acid tert-butyl ester→Iodomethane→6-Chloro-4-iodo-N-methyl-N-Boc-pyridin-3-amine→6-Chloro-4-iodo-N-methylpyridin-3-amine→4-Fluoro-2-methylphenylboronic acid→6-Chloro-4-(4-fluoro-2-methylphenyl)-N-methylpyridin-3-amine→2-[3,5-Bis(trifluoromethyl)phenyl]-2-methylpropanoyl chloride→2-[3,5-Bis(trifluoromethyl)phenyl]-N-[6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl]-N,2-dimethylpropanamide→(7S,9aS)-7-([[tert-Butyl(dimethyl)silyl]oxy]methyl)octahydropyrazino[2,1-c][1,4]oxazine→2-[3,5-Bis(trifluoromethyl)phenyl]-N-[6-[(7S,9aS)-7-([[tert-butyl(dimethyl)silyl]oxy]methyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-4-(4-fluoro-2-methylphenyl)pyridin-3-yl]-N,2-dimethylpropanamide
2-[3,5-Bis(trifluoromethyl)phenyl]-N-[6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl]-N,2-dimethylpropanamide→4-Chloro-5-nitropyridin-2(1H)-one→2-[3,5-Bis(trifluoromethyl)phenyl]-2-methylpropanoyl chloride→4-Fluoro-2-methylphenylboronic acid→4-(4-Fluoro-2-methylphenyl)-5-nitropyridin-2(1H)-one→2-Chloro-4-(4-fluoro-2-methylphenyl)-5-nitropyridine→6-Chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-amine hydrogen chloride (1/1)→2-[3,5-Bis(trifluoromethyl)phenyl]-2-methylpropanoic acid→2-[3,5-Bis(trifluoromethyl)phenyl]-N-[6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl]-2-methylpropanamide→Iodomethane
6-(4-methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide→FOSNE-008→methyl (6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbamate→N-methyl-6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine→2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoyl chloride→FOSNE-012→di-tert-butyl (chloromethyl) phosphate→FOSNE-014→2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoic acid→FOSNE-016→FOSNE-017→FOSNE-018→FOSNE-019→Fosnetupitant→6-chloronicotinic acid→o-tolylmagnesium chloride→FOSNE-003→FOSNE-004→FOSNE-005→1-methylpiperazine
6-chloronicotinic acid→6-chloronicotinoyl chloride→N-(tert-butyl)-6-chloronicotinamide→o-tolylmagnesium chloride→N-(tert-butyl)-6-chloro-4-(o-tolyl)nicotinamide→N-(tert-butyl)-6-(4-methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide→6-(4-methylpiperazin-1-yl)-4-(o-tolyl)nicotinamide→methyl (6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-yl)carbamate→N-methyl-6-(4-methylpiperazin-1-yl)-4-(o-tolyl)pyridin-3-amine→2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropanoyl chloride
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications | Action |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 2-(3,5-bis-trifluoromethylphenyl)-2-methyl-propionyl chloride Pharmaceutical Intermediates | On request | On request | On request | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.