CAS 298-12-4

2-oxoacetic acid

Codes: BRIV-002, LAMI-021, EMTR-029, TELAP-041, VILD-020, Vornorexant-002

Application context (from source-drug indications)

Partial-onset seizureBrivaracetamEpilepsyBrivaracetamSeizureBrivaracetamHIV infectionDolutegravir/Lamivudine/Tenofovir AlafenamideHIV infectionLamivudine/Tenofovir Disoproxil FumarateChronic hepatitis BLamivudine/Tenofovir Disoproxil FumarateHIV infectionBictegravir/Emtricitabine/Tenofovir Alafenamide FumarateHepatitis BBictegravir/Emtricitabine/Tenofovir Alafenamide FumarateHIV infectionEfavirenz/Lamivudine/Tenofovir Disoproxil FumarateHIV infectionEmtricitabine/Tenofovir Alafenamide FumarateAcquired immunodeficiency syndromeEmtricitabine/Tenofovir Alafenamide FumarateProgressive multifocal leukoencephalopathyEmtricitabine/Tenofovir Alafenamide FumarateHIV infectionEmtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil FumarateHepatitis CTelaprevirChronic hepatitis CTelaprevirHIV infectionTelaprevirHepatic function declineTelaprevirOpioid dependenceTelaprevirKidney diseaseTelaprevirType 2 diabetesVildagliptinSchizophreniaVildagliptinDyslipidaemiaVildagliptinInsulin resistanceVildagliptinType 1 diabetesVildagliptinDiabetesVildagliptinHepatitis BLamivudineChronic hepatitis BLamivudineHIV infectionLamivudineRett syndromeLamivudineAlzheimer's diseaseLamivudineRetinal detachmentLamivudineHIV infectionEmtricitabineAlzheimer's diseaseEmtricitabineDementiaEmtricitabineMild cognitive impairmentEmtricitabineInsomnia and sleep disordersVornorexantHepatic function declineVornorexant睡眠呼吸暂停Vornorexant

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Brivaracetam	Tier C — Watch / trade	2028
Dolutegravir/Lamivudine/Tenofovir Alafenamide	Tier C — Watch / trade	-
Lamivudine/Tenofovir Disoproxil Fumarate	Tier C — Watch / trade	-
Bictegravir/Emtricitabine/Tenofovir Alafenamide Fumarate	Tier B — Position early	-
Efavirenz/Lamivudine/Tenofovir Disoproxil Fumarate	Tier C — Watch / trade	-
Emtricitabine/Tenofovir Alafenamide Fumarate	Tier B — Position early	-
Emtricitabine/Rilpivirine Hydrochloride/Tenofovir Disoproxil Fumarate	Tier B — Position early	-
Telaprevir	Tier B — Position early	-
Vildagliptin	Tier B — Position early	-
Lamivudine	Tier C — Watch / trade	-
Emtricitabine	Tier C — Watch / trade	-
Vornorexant	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

BrivaracetamOriginator routesteps: 4total yield: 7.2 g

pentanal→2-oxoacetic acid→morpholine hydrochloride→5-hydroxy-4-propylfuran-2(5H)-one→(S)-2-aminobutanamide→(S)-2-(2-oxo-4-propyl-2,5-dihydro-1H-pyrrol-1-yl)butanamide→(S)-2-((S)-2-oxo-4-propylpyrrolidin-1-yl)butanamide→(S)-2-((R)-2-oxo-4-propylpyrrolidin-1-yl)butanamide

Dolutegravir/Lamivudine/Tenofovir AlafenamideOptimised routesteps: 5total yield: /

(1R,2S,5R)-2-isopropyl-5-methylcyclohexan-1-ol→(2R,5S)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-acetoxy-1,3-oxathiolane-2-carboxylate→2-mercaptoacetic acid→2-oxoacetic acid→5-oxo-1,3-oxathiolane-2-carboxylic acid→(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-oxo-1,3-oxathiolane-2-carboxylate→(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-hydroxy-1,3-oxathiolane-2-carboxylate→(2S,5R)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-acetoxy-1,3-oxathiolane-2-carboxylate

Lamivudine/Tenofovir Disoproxil FumarateOptimised routesteps: 5total yield: /

Bictegravir/Emtricitabine/Tenofovir Alafenamide FumarateOptimised routesteps: 5total yield: 45 mg

1,4-dithiane-2,5-diol→2-oxoacetic acid→5-hydroxy-1,3-oxathiolane-2-carboxylic acid→(2R,5R)-5-acetoxy-1,3-oxathiolane-2-carboxylic acid→(1R,2S,5R)-2-isopropyl-5-methylcyclohexan-1-ol→(2R,5R)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-acetoxy-1,3-oxathiolane-2-carboxylate→4-amino-5-fluoropyrimidin-2(1H)-one→(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate

Bictegravir/Emtricitabine/Tenofovir Alafenamide FumarateOptimised routesteps: 6total yield: 80 g

5-fluoro-N-(trimethylsilyl)-2-((trimethylsilyl)oxy)pyrimidin-4-amine→1,4-dithiane-2,5-diol→2-oxoacetic acid→(1R,2S,5R)-2-isopropyl-5-methylcyclohexan-1-ol→(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 2-oxoacetate→(2R,5S)-(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 5-hydroxy-1,3-oxathiolane-2-carboxylate→(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5R)-5-chloro-1,3-oxathiolane-2-carboxylate→(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(4-amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate oxalate→4-amino-5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one hydrochloride

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications	Action
Unibest Taizhou GMP-like Site	Brivaracetam Pharmaceutical Intermediates	On request	On request	On request	—
Qualified Partner — East China API Works	(+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one Pharmaceutical Intermediates	On request	On request	On request	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.