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CAS 4301-14-8
(Ethynyl)magnesium bromideethynylmagnesium bromide
Codes: Astaxanthin-009, CENSA-026
Application context (from source-drug indications)
营养失调AstaxanthinKnee arthritisAstaxanthinDiabetic neuropathyAstaxanthinStrokeAstaxanthin进行性核上性麻痹CensavudineFrontotemporal dementiaCensavudineAmyotrophic lateral sclerosisCensavudineAicardi综合征CensavudineHIV infectionCensavudine
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Astaxanthin | Tier C — Watch / trade | - |
| Censavudine | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
(E)-beta-Ionone→2,4,4-Trimethyl-3-[(1E)-3-oxobut-1-en-1-yl]cyclohex-2-en-1-one→2,4,4-Trimethyl-3-[(E)-2-(2-methyl-1,3-dioxolan-2-yl)ethenyl]cyclohex-2-en-1-one→Trimethyl([4,4,6-trimethyl-5-[(E)-2-(2-methyl-1,3-dioxolan-2-yl)ethenyl]cyclohexa-1,5-dien-1-yl]oxy)silane→6-Hydroxy-2,4,4-trimethyl-3-[(E)-2-(2-methyl-1,3-dioxolan-2-yl)ethenyl]cyclohex-2-en-1-one→3-Hydroxy-4-oxo-beta-ionone→4-Chlorobenzoic acid chloride→3,5,5-Trimethyl-2-oxo-4-[(1E)-3-oxobut-1-en-1-yl]cyclohex-3-en-1-yl 4-chlorobenzoate→(Ethynyl)magnesium bromide→4-[(1E)-3-Hydroxy-3-methylpent-1-en-4-yn-1-yl]-3,5,5-trimethyl-2-oxocyclohex-3-en-1-yl 4-chlorobenzoate→4-[(1E)-3-Hydroxy-3-methylpenta-1,4-dien-1-yl]-3,5,5-trimethyl-2-oxocyclohex-3-en-1-yl 4-chlorobenzoate→6-Hydroxy-3-[(1E)-3-hydroxy-3-methylpenta-1,4-dien-1-yl]-2,4,4-trimethylcyclohex-2-en-1-one→3-[(1E,3E)-5-Bromo-3-methylpenta-1,3-dien-1-yl]-6-hydroxy-2,4,4-trimethylcyclohex-2-en-1-one→[(2E,4E)-5-(4-Hydroxy-2,6,6-trimethyl-3-oxocyclohex-1-en-1-yl)-3-methylpenta-2,4-dien-1-yl](triphenyl)phosphanium bromide→(2E,4E,6E)-2,7-Dimethylocta-2,4,6-trienedial
1-Chloroethylene→Chlorido(ethenyl)magnesium→Acetylene→1-Buten-3-one→(2E)-3-Methylpent-2-en-4-yn-1-ol→2-Hydroxyethyl methyl ketone→(Ethynyl)magnesium bromide→3-Methylpent-4-yne-1,3-diol
5-methylpyrimidine-2,4(1H,3H)-dione→isopropyl acetate→acrylaldehyde→isopropyl 3-hydroxypent-4-enoate→isopropyl 3-(methoxymethoxy)pent-4-enoate→isopropyl 4,5-dihydroxy-3-(methoxymethoxy)pentanoate→isopropyl 5-((tert-butyldimethylsilyl)oxy)-4-hydroxy-3-(methoxymethoxy)pentanoate→isopropyl 5-((tert-butyldimethylsilyl)oxy)-3-(methoxymethoxy)-4-oxopentanoate→ethynylmagnesium bromide→isopropyl (3S,4R)-4-(((tert-butyldimethylsilyl)oxy)methyl)-4-hydroxy-3-(methoxymethoxy)hex-5-ynoate→(4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-ethynyl-4-(methoxymethoxy)tetrahydrofuran-2-ol→(4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-ethynyl-4-(methoxymethoxy)tetrahydrofuran-2-yl acetate→1-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-ethynyl-4-(methoxymethoxy)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione→1-((2R,4S,5R)-5-ethynyl-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione→1-((2R,4S,5R)-5-(((tert-butyldimethylsilyl)oxy)methyl)-5-ethynyl-4-hydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione→(2R,3S,5R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-2-ethynyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl methanesulfonate→1-((2R,5R)-5-ethynyl-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
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