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CAS 78-94-4
1-Buten-3-onebut-3-en-2-one
Codes: Astaxanthin-017, GALU-002
Application context (from source-drug indications)
营养失调AstaxanthinKnee arthritisAstaxanthinDiabetic neuropathyAstaxanthinStrokeAstaxanthinAmyotrophic lateral sclerosisGalunisertibPeritoneal cancerGalunisertibNasopharyngeal carcinomaGalunisertibColorectal cancerGalunisertibProstate cancerGalunisertibRectal cancerGalunisertib
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Astaxanthin | Tier C — Watch / trade | - |
| Galunisertib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
6-Hydroxy-3-[(1E)-3-hydroxy-3-methylpenta-1,4-dien-1-yl]-2,4,4-trimethylcyclohex-2-en-1-one→Acetylene→1-Buten-3-one→Lithium 3-methylpent-1-en-4-yn-3-olate→Dilithium 3-methylpent-4-en-1-yn-1-id-3-olate→2,2,4,6,6-Pentamethyl-7,7a-dihydro-1,3-benzodioxol-5-one→Dilithium 2,2,4,6,6-pentamethyl-5-(3-methyl-3-oxidopent-4-en-1-yn-1-yl)-5,6,7,7a-tetrahydro-2H-1,3-benzodioxol-5-olate→6-Hydroxy-3-(3-hydroxy-3-methylpent-4-en-1-yn-1-yl)-2,4,4-trimethylcyclohex-2-en-1-one→6-Hydroxy-3-[(1E)-3-hydroxy-3-methylpenta-1,4-dien-1-yl]-2,4,4-trimethylcyclohexa-2,5-dien-1-one
1-Chloroethylene→Chlorido(ethenyl)magnesium→Acetylene→1-Buten-3-one→(2E)-3-Methylpent-2-en-4-yn-1-ol→2-Hydroxyethyl methyl ketone→(Ethynyl)magnesium bromide→3-Methylpent-4-yne-1,3-diol
4-bromoaniline→but-3-en-2-one→6-bromo-4-methylquinoline→methyl 6-methylpicolinate→2-(6-bromoquinolin-4-yl)-1-(6-methylpyridin-2-yl)ethan-1-one→1-aminopyrrolidin-2-one hydrochloride→(Z)-1-((2-(6-bromoquinolin-4-yl)-1-(6-methylpyridin-2-yl)ethylidene)amino)pyrrolidin-2-one→6-bromo-4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline→methyl 4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline-6-carboxylate
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