← Back to patent-cliff list
CAS 638-07-3
Ethyl 4-chloro-3-oxobutanoate4-Chloro-3-oxobutyric acid ethyl esterEthyl 4-chloroacetoacetateethyl 4-chloro-3-oxobutanoate
Codes: (I)109067-1-a, (I)109067-2-a, (I)109067-3-a, (III)109067-4-a, (IV)109067-5-a, (II)109067-8-a,(II)109067-8-b, (III)109067-10-a, TIPIRA-002
Application context (from source-drug indications)
HypertensionOlmesartan Medoxomil/Amlodipine orotateEssential hypertensionValsartan/Amlodipine OrotateVariant anginaAmlodipine OrotateHypertensionAmlodipine OrotateIschaemic heart diseaseAmlodipine OrotateStable anginaAmlodipine OrotateHypertensionAmlodipine CamsylateHypertensionAmlodipine MaleateAngina pectorisAmlodipine MaleateChronic renal impairmentAmlodipine Maleate肾性高血压Amlodipine MaleateHeart diseaseAmlodipine Maleate血管疾病Amlodipine MaleateOesophageal cancerTipiracil HydrochlorideGastric cancerTipiracil HydrochlorideAdenocarcinomaTipiracil Hydrochloride
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Olmesartan Medoxomil/Amlodipine orotate | Tier C — Watch / trade | - |
| Valsartan/Amlodipine Orotate | Tier C — Watch / trade | - |
| Amlodipine Orotate | Tier C — Watch / trade | - |
| Amlodipine Camsylate | Tier C — Watch / trade | - |
| Amlodipine Maleate | Tier C — Watch / trade | - |
| Tipiracil Hydrochloride | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
Ethyl 4-chloro-3-oxobutanoate→Ethyl 4-[(4-methylbenzene-1-sulfonyl)oxy]-3-oxobutanoate→N-(2-Hydroxyethyl)phthalimide→Ethyl 4-(2-phthalimidoethoxy)acetoacetate→Ethyl (2Z)-3-amino-4-[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]but-2-enoate→Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate→3-Ethyl 5-methyl (4RS)-4-(2-chlorophenyl)-2-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethoxy]methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
Diethoxyacetic acid ethyl ester→2,2-Diethoxyethanol→4-Chloro-3-oxobutyric acid ethyl ester→ethyl 4-(2,2-diethoxyethoxy)-3-oxobutanoate→2-Chlorobenzaldehyde→ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-4-(2,2-dimethoxyethoxy)-3-oxobutanoate→Methyl 3-amino-2-butenoate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(2,2-dimethoxyethoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→ethyl (2E)-3-amino-4-(2,2-diethoxyethoxy)but-2-enoate→Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate
2-Aminoethanol→(2-chloro-1,1-diphenylethyl)benzene→2-[(triphenylmethyl)amino]ethan-1-ol→Ethyl 4-chloroacetoacetate→ethyl 3-oxo-4-{2-[(triphenylmethyl)amino]ethoxy}butanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-({2-[(triphenylmethyl)amino]ethoxy}methyl)-1,4-dihydropyridine-3,5-dicarboxylate
Intermediates available on this site
No listed intermediates for this target yet — send an RFQ directly and it will enter our matching pool.
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.