CAS 89-98-5

2-Chlorobenzaldehyde2-chlorobenzaldehyde

Codes: (V)109067-1-a, (V)109067-4-a, (VI)109067-5-a, (VII)109067-6-a, (IV)109067-8-a,(IV)109067-8-b, Levamlodipine Besylate-010, (VI)109067-10-a, Sephin-1-001, JBPOS-0101-001

Application context (from source-drug indications)

HypertensionOlmesartan Medoxomil/Amlodipine orotateEssential hypertensionValsartan/Amlodipine OrotateHypertensionLevamlodipine BesylateAngina pectorisLevamlodipine BesylateEssential hypertensionLevamlodipine BesylateVariant anginaAmlodipine OrotateHypertensionAmlodipine OrotateIschaemic heart diseaseAmlodipine OrotateStable anginaAmlodipine OrotateHypertensionAmlodipine CamsylateHypertensionAmlodipine MaleateAngina pectorisAmlodipine MaleateChronic renal impairmentAmlodipine Maleate肾性高血压Amlodipine MaleateHeart diseaseAmlodipine Maleate血管疾病Amlodipine MaleateAmyotrophic lateral sclerosisIcerguastat夏科-马里-图斯病Icerguastat婴儿痉挛JBPOS-0101EpilepsyJBPOS-0101

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
Olmesartan Medoxomil/Amlodipine orotate	Tier C — Watch / trade	-
Valsartan/Amlodipine Orotate	Tier C — Watch / trade	-
Levamlodipine Besylate	Tier C — Watch / trade	-
Amlodipine Orotate	Tier C — Watch / trade	-
Amlodipine Camsylate	Tier C — Watch / trade	-
Amlodipine Maleate	Tier C — Watch / trade	-
Icerguastat	Tier C — Watch / trade	-
JBPOS-0101	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

Olmesartan Medoxomil/Amlodipine orotateOptimised routesteps: 3total yield: /

Ethyl 4-chloro-3-oxobutanoate→2-azidoethan-1-ol→ethyl 4-(2-azidoethoxy)-3-oxobutanoate→3-Amino-2-butenoic acid methyl ester→2-Chlorobenzaldehyde→3-ethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Olmesartan Medoxomil/Amlodipine orotateOptimised routesteps: 6total yield: /

Diethoxyacetic acid ethyl ester→2,2-Diethoxyethanol→4-Chloro-3-oxobutyric acid ethyl ester→ethyl 4-(2,2-diethoxyethoxy)-3-oxobutanoate→2-Chlorobenzaldehyde→ethyl (2Z)-2-[(2-chlorophenyl)methylidene]-4-(2,2-dimethoxyethoxy)-3-oxobutanoate→Methyl 3-amino-2-butenoate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(2,2-dimethoxyethoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→ethyl (2E)-3-amino-4-(2,2-diethoxyethoxy)but-2-enoate→Methyl (2Z)-2-[(2-chlorophenyl)methylidene]-3-oxobutanoate

Olmesartan Medoxomil/Amlodipine orotateOptimised routesteps: 4total yield: /

2-Aminoethanol→(2-chloro-1,1-diphenylethyl)benzene→2-[(triphenylmethyl)amino]ethan-1-ol→Ethyl 4-chloroacetoacetate→ethyl 3-oxo-4-{2-[(triphenylmethyl)amino]ethoxy}butanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-({2-[(triphenylmethyl)amino]ethoxy}methyl)-1,4-dihydropyridine-3,5-dicarboxylate

Olmesartan Medoxomil/Amlodipine orotateOptimised routesteps: 8total yield: /

2-azidoethan-1-ol→2-Chloroacetic acid→2-(2-azidoethoxy)acetic acid→2,2-Dimethyl-1,3-dioxane-4,6-dione→3-Hydroxypropionitrile→2-cyanoethyl 4-(2-azidoethoxy)-3-oxobutanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-(2-cyanoethyl) 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridine-3-carboxylic acid→(2S)-2-methoxy-2-phenylethan-1-ol→3-(2S)-2-methoxy-2-phenylethyl 5-methyl 2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-[(2S)-2-Methoxy-2-phenylethyl] 5-methyl (4S)-2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-Ethyl 5-methyl (4S)-2-[(2-azidoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-Ethyl 5-methyl (4S)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Olmesartan Medoxomil/Amlodipine orotateOptimised routesteps: 6total yield: /

[5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methanol→4-Chloro-3-oxobutyric acid ethyl ester→ethyl 4-({5-[(4-ethoxy-2,4-dioxobutoxy)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}methoxy)-3-oxobutanoate→2-Chlorobenzaldehyde→3-Amino-2-butenoic acid methyl ester→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-({[5-({[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}methyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methoxy}methyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-[(4-{[4-(2-chlorophenyl)-3-(ethoxycarbonyl)-5-(methoxycarbonyl)-6-methyl-1,4-dihydropyridin-2-yl]methoxy}-2,3-dihydroxybutoxy)methyl]-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-6-methyl-2-[(2-oxoethoxy)methyl]-1,4-dihydropyridine-3,5-dicarboxylate→3-ethyl 5-methyl 4-(2-chlorophenyl)-2-{[(2E)-2-(hydroxyimino)ethoxy]methyl}-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

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