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CAS 2549-14-6
(R)-2-amino-1-phenylethanol(R)-2-amino-2-phenylethan-1-ol
Codes: MIRA-019, Vornorexant-006
Application context (from source-drug indications)
Neurogenic bladder dysfunctionMirabegronOveractive bladderMirabegronInsomnia and sleep disordersVornorexantHepatic function declineVornorexant睡眠呼吸暂停Vornorexant
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| Mirabegron | Tier B — Position early | 2029 |
| Vornorexant | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
2-(2-aminothiazol-4-yl)acetic acid→(R)-2-((4-aminophenethyl)amino)-1-phenylethan-1-ol→2-(4-aminophenyl)ethanol→tert-butyl (4-(2-hydroxyethyl)phenyl)carbamate→tert-butyl (4-(2-oxoethyl)phenyl)carbamate→(R)-2-amino-1-phenylethanol→tert-butyl (R)-(4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)carbamate
(R)-2-amino-1-phenylethanol→2-(2-aminothiazol-4-yl)acetic acid hydrochloride→2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetic acid→2-(2-(benzylamino)thiazol-4-yl)acetic acid→2-(2-((ethoxycarbonyl)amino)thiazol-4-yl)acetic acid→4-(2-bromoethyl)aniline hydrochloride→4-(2-chloroethyl)aniline hydrochloride→tert-butyl (4-(2-((4-(2-bromoethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate→2-(2-(benzylamino)thiazol-4-yl)-N-(4-(2-bromoethyl)phenyl)acetamide→ethyl (4-(2-((4-(2-chloroethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate→tert-butyl (4-(2-((4-(2-chloroethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate→tert-butyl (R)-(4-(2-((4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate→(R)-2-(2-(benzylamino)thiazol-4-yl)-N-(4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)acetamide→ethyl (R)-(4-(2-((4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate
2-(4-aminophenyl)ethanol→(R)-2-amino-1-phenylethanol→2-(2-aminothiazol-4-yl)acetic acid hydrochloride→2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)acetic acid→tert-butyl (R)-(4-(2-((4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate→2-(2-(((benzyloxy)carbonyl)amino)thiazol-4-yl)acetic acid→2-(2-(tritylamino)thiazol-4-yl)acetic acid→tert-butyl (4-(2-((4-(2-hydroxyethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate→benzyl (4-(2-((4-(2-hydroxyethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate→N-(4-(2-hydroxyethyl)phenyl)-2-(2-(tritylamino)thiazol-4-yl)acetamide→tert-butyl (4-(2-oxo-2-((4-(2-oxoethyl)phenyl)amino)ethyl)thiazol-2-yl)carbamate→benzyl (4-(2-oxo-2-((4-(2-oxoethyl)phenyl)amino)ethyl)thiazol-2-yl)carbamate→N-(4-(2-oxoethyl)phenyl)-2-(2-(tritylamino)thiazol-4-yl)acetamide→benzyl (R)-(4-(2-((4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)amino)-2-oxoethyl)thiazol-2-yl)carbamate→(R)-2-(2-((l1-phosphanyl)amino)thiazol-4-yl)-N-(4-(2-((2-hydroxy-2-phenylethyl)amino)ethyl)phenyl)acetamide
3-aminopropan-1-ol→2-oxoacetic acid→1,3-oxazinane-2-carboxylic acid→benzyl carbonochloridate→3-((benzyloxy)carbonyl)-1,3-oxazinane-2-carboxylic acid→(R)-2-amino-2-phenylethan-1-ol→(S)-3-((benzyloxy)carbonyl)-1,3-oxazinane-2-carboxylic acid, (R)-2-amino-2-phenylethan-1-ol→(S)-3-((benzyloxy)carbonyl)-1,3-oxazinane-2-carboxylic acid→3-benzyl 2-methyl (S)-1,3-oxazinane-2,3-dicarboxylate→methyl (S)-1,3-oxazinane-2-carboxylate→5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl chloride→methyl (S)-3-(5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoyl)-1,3-oxazinane-2-carboxylate→(S)-(2-(hydroxymethyl)-1,3-oxazinan-3-yl)(5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone→5-fluoro-2-(1-(methylsulfonyl)-1H-pyrazol-3-yl)pyridine→1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole→2-chloro-5-fluoropyridine→5-fluoro-2-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)pyridine→5-fluoro-2-(1H-pyrazol-3-yl)pyridine→5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid
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